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Cys-loop receptors: new twists and turns

Lester, Henry A. and Dibas, Mohammed I. and Dahan, David S. and Leite, John F. and Dougherty, Dennis A. (2004) Cys-loop receptors: new twists and turns. Trends in Neurosciences, 27 (6). pp. 329-336. ISSN 0166-2236. doi:10.1016/j.tins.2004.04.002.

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New hypotheses and predictions have arisen from recent work revealing atomic-scale or near-atomic-scale structures of receptors in the ‘Cys-loop’ superfamily. How general is the cation–π interaction between the natural ligand and a tryptophan residue in the aromatic box, and does this interaction extend to other ligands? What is the pathway from the binding site to gating, and what are the conformational changes during gating and desensitization? Is current flow through intracellular ‘portals’ in the wall of the channel a general feature? This article discusses these and related questions, emphasizing nicotinic ACh receptors and also discussing data from other members of this superfamily.

Item Type:Article
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Lester, Henry A.0000-0002-5470-5255
Dougherty, Dennis A.0000-0003-1464-2461
Additional Information:© 2004 Elsevier Ltd. Available online 14 April 2004. We thank members of our research groups for comments and the NIH (NS11756 and NS34407) for support.
Funding AgencyGrant Number
Issue or Number:6
Record Number:CaltechAUTHORS:20200427-094708016
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Official Citation:Henry A. Lester, Mohammed I. Dibas, David S. Dahan, John F. Leite, Dennis A. Dougherty, Cys-loop receptors: new twists and turns, Trends in Neurosciences, Volume 27, Issue 6, 2004, Pages 329-336, ISSN 0166-2236, (
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:102795
Deposited By: Tony Diaz
Deposited On:27 Apr 2020 17:01
Last Modified:16 Nov 2021 18:15

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