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CNS Localization of Neuronal Nicotinic Receptors

Nashmi, Raad and Lester, Henry A. (2006) CNS Localization of Neuronal Nicotinic Receptors. Journal of Molecular Neuroscience, 30 (1-2). pp. 181-184. ISSN 0895-8696. https://resolver.caltech.edu/CaltechAUTHORS:20200427-134509446

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Abstract

Nicotinic acetylcholine receptors (nAChRs) are members of the Cys-loop superfamily of pentameric ligand-gated ion channels, which include GABA (A and C), serotonin, and glycine receptors. Currently, 12 neuronal nAChR subunits have been identified (α2–10 and β2–4) and are generally grouped into α subunits, which contain two adjacent cysteine residues essential for ACh binding, and α subunits, which lack these residues. The majority of neuronal nAChRs fall into two categories: those that bind agonist with high affinity (nMconcentrations); and those that bind with lower affinity (µM concentrations). The low-affinity receptors are presumably homomeric α7 receptors that are α-bungarotoxin sensitive, whereas α4β2 nAChRs account for >90% of the high-affinity nicotinic receptors in the brain (Whiting and Lindstrom, 1986). Their physiological contributions to neurotransmission, signaling, and behavior are not completely understood. Precise mapping of subcellular and neuroanatomical localizations of neuronal nAChR subunits will help elucidate the physiological role of neuronal nAChRs and their role in nicotine addiction.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1385/jmn:30:1:181DOIArticle
https://rdcu.be/b3OP4PublisherFree ReadCube access
ORCID:
AuthorORCID
Lester, Henry A.0000-0002-5470-5255
Additional Information:© 2006 Humana Press Inc. This work was supported by the California Tobacco-Related Disease Research Program (TRDRP; 12RT-0245), National Institutes of Health grants (NS-11756, DA-17279), and the Phillip Morris External Research Program. R. N. was supported by a postdoctoral fellowship from the TRDRP(10FT-0174) and the Elizabeth Ross Fellowship.
Funders:
Funding AgencyGrant Number
California Tobacco-Related Disease Research Program12RT-0245
NIHNS-11756
NIHDA-17279
Phillip Morris External Research ProgramUNSPECIFIED
California Tobacco-Related Disease Research Program10FT-0174
Elizabeth Ross FellowshipUNSPECIFIED
Subject Keywords:Nicotine; Ventral Tegmental Area; Nicotinic Receptor; Molecular Neuroscience Volume; nAChR Subunit
Issue or Number:1-2
Record Number:CaltechAUTHORS:20200427-134509446
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20200427-134509446
Official Citation:Nashmi, R., Lester, H.A. CNS localization of neuronal nicotinic receptors. J Mol Neurosci 30, 181–184 (2006). https://doi.org/10.1385/JMN:30:1:181
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:102814
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:27 Apr 2020 20:55
Last Modified:27 Apr 2020 20:55

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