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Understanding IAP function and regulation: a view from Drosophila

Hay, B. A. (2000) Understanding IAP function and regulation: a view from Drosophila. Cell Death and Differentiation, 7 (11). pp. 1045-1056. ISSN 1350-9047. doi:10.1038/sj.cdd.4400765.

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Apoptosis is an active form of cell suicide that results in the orderly death and phagocytosis of cells during normal development and in the adult. Many death signals lead to the activation of members of a family of cysteine proteases known as caspases. These proteins act to transduce death signals from different cellular compartments and they cleave a number of cellular proteins, leading ultimately to many of the biochemical and morphological events associated with death. Many mechanisms act to inhibit cell death upstream of caspase activation. However, only one family of cellular proteins, the inhibitors of apoptosis (IAPs), has been identified that inhibit caspase activation and/or activity. The observations that IAP function is essential for cell survival in Drosophila, and that IAP expression is deregulated in many forms of cancer in humans, argue that IAPs are important cell death inhibitors and that deregulation of their function is likely to be important in human disease. Here we review IAP function, with particular reference to insights that study of the Drosophila IAPs has provided. We also discuss some directions for future study. Cell Death and Differentiation (2000) 7, 1045–1056.

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Additional Information:© 2000 Macmillan Publishers Ltd. Received 31 July 2000; Revised 20 August 2000; Accepted 23 August 2000; Published 09 November 2000; Issue Date 01 November 2000. Special thanks to S Vernooy for help with the figures as well as comments on the text. This work was supported by grants from a Burroughs Wellcome Fund New Investigator Award in the pharmacological Sciences, the Ellison Medical Foundation, and NIH grant GM057422-01.
Funding AgencyGrant Number
Burroughs Wellcome FundUNSPECIFIED
Ellison Medical FoundationUNSPECIFIED
Subject Keywords:caspase; IAP; inhibitor of apoptosis; Drosophila; Reaper; Hid
Issue or Number:11
Record Number:CaltechAUTHORS:20200428-082943830
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Official Citation:Hay, B. Understanding IAP function and regulation: a view from Drosophila. Cell Death Differ 7, 1045–1056 (2000).
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:102831
Deposited By: Tony Diaz
Deposited On:28 Apr 2020 15:36
Last Modified:16 Nov 2021 18:15

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