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Hypersensitive knockin mouse strains identify receptors and pathways for nicotine action

Lester, Henry A. and Fonck, Carlos and Tapper, Andrew R. and McKinney, Sheri and Damaj, M. Imad and Balogh, Seth and Owens, Jeremy and Wehner, Jeanne M. and Collins, Allan C. and Labarca, Cesar (2003) Hypersensitive knockin mouse strains identify receptors and pathways for nicotine action. Current opinion in drug discovery & development, 6 (5). pp. 633-639. ISSN 1367-6733.

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Two series of knockin mouse strains have been constructed with point mutations that result in hypersensitive neuronal nicotinic acetylcholine receptors containing α₄- or α₇-subunits. The full expression of the stronger alleles produces neonatal excitotoxic lethality; however, mice with attenuated expression or milder alleles are viable, and display a range of hypersensitive responses to nicotine. To date, measurements have been made on nicotine-induced seizures, Straub tail, hypothermia, antinociception, electroencephalograms and cellular electrophysiological responses. These strains are helping to define the occurrence of these important receptor subtypes, and their role in the acute and chronic actions of nicotine. The hypersensitive strains may be useful for the development of nicotinic drug therapy.

Item Type:Article
Lester, Henry A.0000-0002-5470-5255
Additional Information:© 2003 Current Drugs.
Issue or Number:5
Record Number:CaltechAUTHORS:20200428-093705406
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:102839
Deposited By: George Porter
Deposited On:28 Apr 2020 17:02
Last Modified:28 Apr 2020 17:02

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