Lou, Sha and Fu, Gregory C. (2010) Enantioselective Alkenylation via Nickel-Catalyzed Cross-Coupling with Organozirconium Reagents. Journal of the American Chemical Society, 132 (14). pp. 5010-5011. ISSN 0002-7863. PMCID PMC2860276. doi:10.1021/ja1017046. https://resolver.caltech.edu/CaltechAUTHORS:20200428-095146456
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Abstract
A new family of organometallic compounds, organozirconium reagents, are shown to serve as suitable partners in cross-coupling reactions of (activated) secondary alkyl electrophiles. Thus, the first catalytic method for coupling secondary α-bromoketones with alkenylmetal reagents has been developed, specifically, a mild, versatile, and stereoconvergent carbon−carbon bond-forming process that generates potentially labile β,γ-unsaturated ketones with good enantioselectivity.
| Item Type: | Article | |||||||||
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| Additional Information: | © 2010 American Chemical Society. Received February 28, 2010. Support has been provided by the National Institutes of Health (National Institute of General Medical Sciences, Grant R01-GM62871), Merck Research Laboratories, and Novartis. We thank Shaun D. Fontaine, Dr. Peter Mueller, and Dr. Michael R. Reithofer for assistance. | |||||||||
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| Issue or Number: | 14 | |||||||||
| PubMed Central ID: | PMC2860276 | |||||||||
| DOI: | 10.1021/ja1017046 | |||||||||
| Record Number: | CaltechAUTHORS:20200428-095146456 | |||||||||
| Persistent URL: | https://resolver.caltech.edu/CaltechAUTHORS:20200428-095146456 | |||||||||
| Official Citation: | Enantioselective Alkenylation via Nickel-Catalyzed Cross-Coupling with Organozirconium Reagents. Sha Lou and Gregory C. Fu. Journal of the American Chemical Society 2010 132 (14), 5010-5011; DOI: 10.1021/ja1017046 | |||||||||
| Usage Policy: | No commercial reproduction, distribution, display or performance rights in this work are provided. | |||||||||
| ID Code: | 102860 | |||||||||
| Collection: | CaltechAUTHORS | |||||||||
| Deposited By: | George Porter | |||||||||
| Deposited On: | 29 Apr 2020 20:10 | |||||||||
| Last Modified: | 16 Nov 2021 18:16 |
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