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Physiological functions for brain NF-κB

Meffert, Mollie K. and Baltimore, David (2005) Physiological functions for brain NF-κB. Trends in Neurosciences, 28 (1). pp. 37-43. ISSN 0166-2236. doi:10.1016/j.tins.2004.11.002.

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Members of the nuclear factor κB (NF-κB) family of transcription factors are activated within the CNS in pathological settings of apoptosis and neurological disease. Recent work using several model systems provides accumulating evidence that these transcription factors also participate in the regulation of neuronal activity-dependent transcription and behavior under physiological conditions. This review highlights advances in our understanding of the mechanisms of Ca²⁺-responsive activation and synaptic signaling to the nucleus by NF-κB transcription factors within the CNS, and the relevance of this transcription factor family for learning and memory.

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Baltimore, David0000-0001-8723-8190
Additional Information:© 2004 Elsevier Ltd. Available online 13 November 2004. We thank J.L. Pomerantz for critical reading of the manuscript and A. Romano for his assistance in providing a diagram of the crab learning paradigm. M.K.M. is supported by a National Institutes of Neurological Disorders and Stroke (NINDS) K08 grant.
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National Institute of Neurological Disorders and Stroke (NINDS)UNSPECIFIED
Issue or Number:1
Record Number:CaltechAUTHORS:20200428-103522723
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Official Citation:Mollie K. Meffert, David Baltimore, Physiological functions for brain NF-κB, Trends in Neurosciences, Volume 28, Issue 1, 2005, Pages 37-43, ISSN 0166-2236, (
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:102873
Deposited By: Tony Diaz
Deposited On:28 Apr 2020 17:45
Last Modified:16 Nov 2021 18:16

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