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MicroRNAs and the regulation of cell death

Xu, Peizhang and Guo, Ming and Hay, Bruce A. (2004) MicroRNAs and the regulation of cell death. Trends in Genetics, 20 (12). pp. 617-624. ISSN 0168-9525. doi:10.1016/j.tig.2004.09.010.

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Programmed cell death, or apoptosis, is ubiquitous, both during development and in the adult. Many components of the evolutionarily conserved machinery that brings about and regulates cell death have been identified, and all of these are proteins. However, in the past three years it has become clear that roughly 1% of predicted genes in animals encode small noncoding RNAs known as microRNAs, which regulate gene function. Here we review the recent identification of microRNA cell death regulators in Drosophila, hints that such regulators are also likely to exist in mammals, and more generally the approaches and tools that are now available to probe roles for noncoding RNAs in the control of cell death.

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Additional Information:© 2004 Elsevier Ltd. Available online 8 October 2004. The authors' work described in this article was supported by The Ellison Medical Foundation, The Margaret E. Early Medical Trust, NIH grants GM070956 and GM57422 (B.A.H.) and a Gosney Fellowship (P.X.). We apologize to authors whose work could not be cited directly due to space limitations.
Funding AgencyGrant Number
Ellison Medical FoundationUNSPECIFIED
Margaret E. Early Medical TrustUNSPECIFIED
Gosney FoundationUNSPECIFIED
Issue or Number:12
Record Number:CaltechAUTHORS:20200428-140118693
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Official Citation:Peizhang Xu, Ming Guo, Bruce A. Hay, MicroRNAs and the regulation of cell death, Trends in Genetics, Volume 20, Issue 12, 2004, Pages 617-624, ISSN 0168-9525, (
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:102884
Deposited By: Tony Diaz
Deposited On:28 Apr 2020 21:47
Last Modified:16 Nov 2021 18:16

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