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Developmental expression of prion protein gene in brain

McKinley, Michael P. and Hay, Bruce and Lingappa, Vishwanath R. and Lieberburg, Ivan and Prusiner, Stanley B. (1987) Developmental expression of prion protein gene in brain. Developmental Biology, 121 (1). pp. 105-110. ISSN 0012-1606. https://resolver.caltech.edu/CaltechAUTHORS:20200429-083757573

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Abstract

Synthesis of the cellular isoform of the prion protein (PrP^C) was found to be regulated during development of the hamster brain. PrP poly A(+) RNA was readily detectable 10 days postpartum; after 20 days of age, no change in its level could be detected through 13 months of age. Low levels of PrP poly A(+) RNA were detectable 1 day after birth. By contrast, myelin basic protein poly A(+) RNA was found at high levels in brain at 30 days of age and thereafter declined steadily. Using monospecific PrP antisera, immunoprecipitable cell-free translation products were detected at low levels 2 days after birth and increased progressively through 10 days of age. How the levels of PrP mRNA participate in brain development and function remains to be established.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1016/0012-1606(87)90143-6DOIArticle
Additional Information:© 1987 Published by Elsevier Inc. Received 16 May 1986, Accepted 13 October 1986. We thank Dr. David Westaway for advice on the RNA analysis and for critical review of the manuscript, Dr. Karen Hsiao for helpful discussions, and Lorraine Gallagher for manuscript preparation. This work was supported by research grants from the National Institutes of Health (AG02132 and NS14069) and a Senator Jacob Javits Center of Excellence in Neuroscience, as well as by gifts from RJR-Nabisco, Inc., and Sherman Fairchild Foundation.
Funders:
Funding AgencyGrant Number
NIHAG02132
NIHNS14069
RJR-NabiscoUNSPECIFIED
Sherman Fairchild FoundationUNSPECIFIED
Issue or Number:1
Record Number:CaltechAUTHORS:20200429-083757573
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20200429-083757573
Official Citation:Michael P. McKinley, Bruce Hay, Vishwanath R. Lingappa, Ivan Lieberburg, Stanley B. Prusiner, Developmental expression of prion protein gene in brain, Developmental Biology, Volume 121, Issue 1, 1987, Pages 105-110, ISSN 0012-1606, https://doi.org/10.1016/0012-1606(87)90143-6. (http://www.sciencedirect.com/science/article/pii/0012160687901436)
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:102899
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:29 Apr 2020 16:24
Last Modified:29 Apr 2020 16:24

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