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Aminopyrrolidineamide inhibitors of site-1 protease

Hay, Bruce A. and Abrams, Barbara and Zumbrunn, Allice Y. and Valentine, James J. and Warren, Laurie C. and Petras, Stephen F. and Shelly, Lorraine D. and Xia, Angela and Varghese, Alison H. and Hawkins, Julie L. and Van Camp, Jennifer A. and Robbins, Michael D. and Landschulz, Katherine and Harwood, H. James, Jr. (2007) Aminopyrrolidineamide inhibitors of site-1 protease. Bioorganic and Medicinal Chemistry Letters, 17 (16). pp. 4411-4414. ISSN 0960-894X. doi:10.1016/j.bmcl.2007.06.031. https://resolver.caltech.edu/CaltechAUTHORS:20200505-150715952

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Abstract

The discovery and efficacy of a series of potent aminopyrrolidineamide-based inhibitors of sterol regulatory element binding protein site-1 protease is described.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1016/j.bmcl.2007.06.031DOIArticle
Additional Information:© 2007 Elsevier Ltd. Received 16 May 2007, Revised 4 June 2007, Accepted 5 June 2007, Available online 10 June 2007. The authors wish to thank Robert Corr, Neal Falcone, Anthony Provatas, Jack Oscarson, and the Pfizer Groton automated synthesis and registration laboratory for preparation of the initial S1P library and Kosea Frederick and Kazuko Sagawa for pharmacokinetic modeling of PF-429242 in rats.
Subject Keywords:Site-1 protease; SREBP; Sterol regulatory element binding protein; Metabolic syndrome
Issue or Number:16
DOI:10.1016/j.bmcl.2007.06.031
Record Number:CaltechAUTHORS:20200505-150715952
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20200505-150715952
Official Citation:Bruce A. Hay, Barbara Abrams, Allice Y. Zumbrunn, James J. Valentine, Laurie C. Warren, Stephen F. Petras, Lorraine D. Shelly, Angela Xia, Alison H. Varghese, Julie L. Hawkins, Jennifer A. Van Camp, Michael D. Robbins, Katherine Landschulz, H. James Harwood, Aminopyrrolidineamide inhibitors of site-1 protease, Bioorganic & Medicinal Chemistry Letters, Volume 17, Issue 16, 2007, Pages 4411-4414, ISSN 0960-894X, https://doi.org/10.1016/j.bmcl.2007.06.031. (http://www.sciencedirect.com/science/article/pii/S0960894X07007123)
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:103007
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:05 May 2020 22:11
Last Modified:16 Nov 2021 18:17

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