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Steering a Course to an AIDS Vaccine

Baltimore, David (2002) Steering a Course to an AIDS Vaccine. Science, 296 (5577). p. 2297. ISSN 0036-8075. doi:10.1126/science.296.5577.2297. https://resolver.caltech.edu/CaltechAUTHORS:20200506-082034309

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Abstract

For more than 20 years, AIDS has been progressing relentlessly and predictably while medical technology has been stymied in its effort to provide a fix. We do have effective drugs, but they treat the infection at great expense and with great difficulty. And we know what will do the job: a safe and effective vaccine. After all, vaccines stopped polio and hepatitis B. The difference is that those viruses are highly sensitive to antibody killing, so the vaccines needed only to induce antibodies. But HIV, the unquestionable cause of AIDS, has evolved to elude antibody killing, thwarting our attempts to induce a broadly protective antibody response, even in animals. A test of an antibody-based vaccine is being run by an optimistic company, but few experts give it much chance of success.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1126/science.296.5577.2297DOIArticle
ORCID:
AuthorORCID
Baltimore, David0000-0001-8723-8190
Additional Information:© 2008 American Association for the Advancement of Science. David Baltimore is president of the California Institute of Technology in Pasadena, California. He was chairman of the AIDS Vaccine Research Committee of the National Institutes of Health from 1997 to 2002.
Issue or Number:5577
DOI:10.1126/science.296.5577.2297
Record Number:CaltechAUTHORS:20200506-082034309
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20200506-082034309
Official Citation:Steering a Course to an AIDS Vaccine. David Baltimore. Science 296 (5577), 2297; DOI: 10.1126/science.296.5577.2297
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:103018
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:06 May 2020 16:06
Last Modified:16 Nov 2021 18:17

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