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HIV's evasion of the cellular immune response

Collins, Kathleen L. and Baltimore, David (1999) HIV's evasion of the cellular immune response. Immunological Reviews, 168 (1). pp. 65-74. ISSN 0105-2896. doi:10.1111/j.1600-065x.1999.tb01283.x.

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Despite a strong cytotoxic T‐lymphocyte (CTL) response directed against viral antigens, untreated individuals infected with the human immunodeficiency virus (HIV‐1) develop AIDS, We have found that primary T cells infected with HIV‐1 downregulate surface MHC class I antigens and are resistant to lysis by HLA‐A2‐restricted CTL clones. In contrast, cells infected with an HIV‐1 in which the nef gene is disrupted are sensitive to CTLs in an MHC and peptide‐specific manner. In primary T cells HLA‐A2 antigens are downmodulated more dramatically than total MHC class I antigens, suggesting that nef selectively downmodulates certain MHC class I antigens. In support of this, studies on ceils expressing individual MHC class I alietes have revealed that nef does not downmodulate HLA‐C and HLA‐E antigens, This selective downmodulation allows Infected cells to maintain resistance to certain natural killer cells that lyse infected cells expressing low levels of MHC class I antigens. Downmodulation of MHC class I HLA‐A2 antigens occurs not only in primary T cells, but also in B and astrocytoma cell lines. No effect of other HIV‐1 accessory proteins such as vpu and vpr was observed. Thus Nef is a protein that may promote escape of HIV‐1 from immune surveillance.

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Baltimore, David0000-0001-8723-8190
Additional Information:© 1999 Wiley. This work was supported at M, I. T, by grants NIH RO1‐AI42549 and by funds from the Ivan R, Cottrell chair. KLC is supported by NIH K08 AI01448. We thank Nancy Hopkins for the gift of pHCMV‐G, Craig Story for the gill of 373 MG astrocytoma cell, Herman Eisen for the gift of JY cells and Ben Chen for the NL4‐3 vpr mutant.
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Massachusetts Institute of Technology (MIT)UNSPECIFIED
NIHK08 AI01448
Issue or Number:1
Record Number:CaltechAUTHORS:20200507-102606426
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Official Citation:Collins, K.L. and Baltimore, D. (1999), HIV's evasion of the cellular immune response. Immunological Reviews, 168: 65-74. doi:10.1111/j.1600-065X.1999.tb01283.x
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:103065
Deposited By: Tony Diaz
Deposited On:08 May 2020 18:14
Last Modified:16 Nov 2021 18:18

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