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Acoustically Targeted Chemogenetics for Noninvasive Control of Neural Circuits

Szablowski, Jerzy and Lee-Gosselin, Audrey and Lue, Brian and Malounda, Dina and Shapiro, Mikhail (2020) Acoustically Targeted Chemogenetics for Noninvasive Control of Neural Circuits. Biological Psychiatry, 87 (9). S95. ISSN 0006-3223. https://resolver.caltech.edu/CaltechAUTHORS:20200507-125032304

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Abstract

Existing treatments for brain disorders aim to modulate the activity of neural circuits, but are either not cell type-specific, lack spatial targeting, or require invasive procedures. Previously, we introduced an approach to modulating neural circuits noninvasively with spatial, cell-type, and temporal specificity called acoustically targeted chemogenetics, or ATAC. We use ultrasound to open the blood brain barrier to transduce neurons at specific locations in the brain with virally-encoded chemogenetic receptors. To show neuronal inhibition expressed inhibitory DREADD (hM4Di) throughout the hippocampus and tested mice in a fear conditioning protocol. The context fear test showed that mice treated with saline froze significantly more than those who had received CNO (p<2E-5, n=7,11) during the training phase.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1016/j.biopsych.2020.02.263DOIArticle
https://resolver.caltech.edu/CaltechAUTHORS:20180108-133221204Related ItemJournal Article
ORCID:
AuthorORCID
Szablowski, Jerzy0000-0001-7851-5408
Lee-Gosselin, Audrey0000-0002-2431-2741
Malounda, Dina0000-0001-7086-9877
Shapiro, Mikhail0000-0002-0291-4215
Additional Information:© 2020 Published by Elsevier Inc. Supported By: NARSAD, Jacobs Institute for Molecular Engineering for Medicine, DARPA.
Group:Jacobs Institute for Molecular Engineering for Medicine
Funders:
Funding AgencyGrant Number
Brain and Behavior Research FoundationUNSPECIFIED
Jacobs Institute for Molecular Engineering for MedicineUNSPECIFIED
Defense Advanced Research Projects Agency (DARPA)UNSPECIFIED
Subject Keywords:CHEMOGENETICS, Ultrasound, Animal Model, AAV, Gene Delivery
Issue or Number:9
Record Number:CaltechAUTHORS:20200507-125032304
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20200507-125032304
Official Citation:Jerzy Szablowski, Audrey Lee-Gosselin, Brian Lue, Dina Malounda, Mikhail Shapiro, Acoustically Targeted Chemogenetics for Noninvasive Control of Neural Circuits, Biological Psychiatry, Volume 87, Issue 9, Supplement, 2020, Page S95, ISSN 0006-3223, https://doi.org/10.1016/j.biopsych.2020.02.263. (http://www.sciencedirect.com/science/article/pii/S0006322320303759)
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:103074
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:07 May 2020 21:06
Last Modified:07 May 2020 21:06

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