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Tissue-regulated differentiation and maturation of a v-abl-immortalized mast cell-committed progenitor

Gurish, Michael F. and Pear, Warren S. and Stevens, Richard L. and Scott, Martin L. and Sokol, Karen and Ghildyal, Namit and Webster, Matthew J. and Hu, Xuzhen and Austen, K. Frank and Baltimore, David and Friend, Daniel S. (1995) Tissue-regulated differentiation and maturation of a v-abl-immortalized mast cell-committed progenitor. Immunity, 3 (2). pp. 175-186. ISSN 1074-7613. doi:10.1016/1074-7613(95)90087-x.

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An immature v-abl-transformed mast cell line (V3-MC) was derived from a mouse that developed systemic mastocytosis after transplantation of v-sbl-infected bone marrow cells. V3-MCs injected intravenously into adult BALE/c mice infiltrated the liver, spleen, and intestine by day 6 and underwent progressive differentiation and maturation, eventually resembling indigenous mast cells. In terms of their protease content, the V3-MCs that localized in the liver and spleen differed from those in the intestine, and both differed from the cultured V3-MCs. The acquired expression of certain proteases and the loss of expression of other proteases in these tissue V3-MCs defines particular phenotypes and Indicates that the differentiation and maturation of mast cell-committed progenitor cells are primarily regulated by factors in the different tissue microenvironments.

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Baltimore, David0000-0001-8723-8190
Additional Information:© 1995 by Cell Press. Received 15 March 1995, Revised 9 June 1995. This work was supported by grants Al-22346, Al-22531, Al-23483, Al-31599, AR-07530, AR-36308, RR-05950, HL-48598, and HL-36110 from the National Institutes of Health, and by a grant from the Hyde and Watson Foundation. W. S. P. was supported by a physician postdoctoral fellowship from the Howard Hughes Medical Institute. We thank Mr. B. Soffer for technical assistance, Dr. J. Flanagan (Harvard Medical School) for the c-kit cDNA, and Dr. N. Rosenberg (Tufts Medical School) for the 24-21 anti-abl monoclonal antibody.
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Hyde and Watson FoundationUNSPECIFIED
Howard Hughes Medical Institute (HHMI)UNSPECIFIED
Issue or Number:2
Record Number:CaltechAUTHORS:20200512-082444534
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Official Citation:Michael F. Gurish, Warren S. Pear, Richard L. Stevens, Martin L. Scott, Karen Sokol, Namit Ghildyal, Matthew J. Webster, Xuzhen Hu, K. Frank Austen, David Baltimore, Daniel S. Friend, Tissue-regulated differentiation and maturation of a v-abl-immortalized mast cell-committed progenitor, Immunity, Volume 3, Issue 2, 1995, Pages 175-186, ISSN 1074-7613, (
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:103125
Deposited By: Tony Diaz
Deposited On:12 May 2020 19:04
Last Modified:16 Nov 2021 18:18

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