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A Nuclear Tyrosine Kinase Becomes a Cytoplasmic Oncogene

Baltimore, David and Ren, Ruibao and Cheng, Genhong and Alexandropoulos, Konstantina and Cicchetti, Piera (1995) A Nuclear Tyrosine Kinase Becomes a Cytoplasmic Oncogene. Annals of the New York Academy of Sciences, 758 (1). pp. 339-344. ISSN 0077-8923. doi:10.1111/j.1749-6632.1995.tb24839.x.

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It is a great pleasure to be here at this celebration. My whole scientific career has, of course, been shaped by the discovery in 1953 of the structure of DNA. At that time I was in high school, and hardly aware of it. But I do remember an incident in the late 1950s when, as a college student, I had the rare opportunity to drive Jim Watson from Cold Spring Harbor to a nearby airport on Long Island. At that time he said to me “There’s a virus that’s just been discovered that has only a small amount of DNA in it.” It had to be SV40 or polyoma virus. “That such a virus is able to cause cancer means that a very small amount of genetic information is all that’s required to cause cancer and we should be able to decipher that very quickly,” he observed. Well, as usual, his insight was remarkable, because those viruses have played a central role in developing the notions of oncogenes; his time line, however, was a little short.

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Baltimore, David0000-0001-8723-8190
Additional Information:© 1995 New York Academy of Sciences. Prepared from a transcript of a paper delivered at the meeting by Dr. David Baltimore.
Issue or Number:1
Record Number:CaltechAUTHORS:20200512-130713713
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Official Citation:BALTIMORE, D., REN, R., CHENG, G., ALEXANDROPOULOS, K. and CICCHETTI, P. (1995), A Nuclear Tyrosine Kinase Becomes a Cytoplasmic Oncogenea. Annals of the New York Academy of Sciences, 758: 339-344. doi:10.1111/j.1749-6632.1995.tb24839.x
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:103144
Deposited By: Tony Diaz
Deposited On:12 May 2020 20:45
Last Modified:16 Nov 2021 18:18

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