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Modular binding domains in signal transduction proteins

Cohen, George B. and Ren, Ruibao and Baltimore, David (1995) Modular binding domains in signal transduction proteins. Cell, 80 (2). pp. 237-248. ISSN 0092-8674. doi:10.1016/0092-8674(95)90406-9.

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The transduction of a signal is a change in form of the signal as it is passed from one carrier to another. The root "duce" means "to lead" in Latin; thus, a signal is led through a cell by steps of transduction (the same root is in the words seduce and duct as well as II Duce). The earliest transduction steps that were elucidated involved massive release of small molecule "second messengers", originally cAMP, that flooded a cell with information. With the understanding that such proteins as tyrosine kinases and Ras relatives are signal transducers, came the realization that many signaling pathways are more precise, sending controlled and probably weakly amplified signals to specific targets. These intracellular signals are often maintained in macromolecular form rather than being passed to small molecules.

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Baltimore, David0000-0001-8723-8190
Additional Information:© 1995 by Cell Press. We would like to thank Martyn Botfield, John Kuriyan, Daniel Oprian, Matti Saraste, Joseph Schlessinger, Stuart Schreiber, Steven Shoelson, and Michael Waterfield for helpful discussions on this manuscript and for communicating results that are in press. We also thank Chi-Hon Lee, John Kuriyan, Andrea Musacchio, and Matti Saraste for redrawing figures for this manuscript, and Structure, Trends in Biochemical Sciences, and Nature Structural Biology, for permission to use previously published figures. We are also grateful to members of the Baltimore laboratory, especially Liz Alcamo and Marty Scott for comments on this manuscript. This work was supported by postdoctoral fellowships from the Helen Hay Whitney Foundation (G. B. C.) and the Cancer Research Institute (R.R.), and National Institutes of Health grant 5RO1 CA51462-06 (D. B.). Space limitation has precluded citation of all primary references, which are included in reviews cited.
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Helen Hay Whitney FoundationUNSPECIFIED
Cancer Research InstituteUNSPECIFIED
NIH5RO1 CA51462-06
Issue or Number:2
Record Number:CaltechAUTHORS:20200512-152740888
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Official Citation:George B Cohen, Ruibao Ren, David Baltimore, Modular binding domains in signal transduction proteins, Cell, Volume 80, Issue 2, 1995, Pages 237-248, ISSN 0092-8674, (
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:103158
Deposited By: Tony Diaz
Deposited On:12 May 2020 22:37
Last Modified:16 Nov 2021 18:18

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