CaltechAUTHORS
  A Caltech Library Service

SH2 and SH3 domains as molecular adhesives: the interactions of Crk and Abl

Feller, Stephan M. and Ren, Ruibao and Hanafusa, Hidesaburo and Baltimore, David (1994) SH2 and SH3 domains as molecular adhesives: the interactions of Crk and Abl. Trends in Biochemical Sciences, 19 (11). pp. 453-458. ISSN 0968-0004. https://resolver.caltech.edu/CaltechAUTHORS:20200513-074221409

Full text is not posted in this repository. Consult Related URLs below.

Use this Persistent URL to link to this item: https://resolver.caltech.edu/CaltechAUTHORS:20200513-074221409

Abstract

The Src homology domains SH2 and SH3 are modular components present in many signal transduction proteins. They allow rapid formation of stable protein complexes and may also regulate protein function through intramolecular binding events. SH2 domains recognize phosphotyrosyl residues in a specific sequence context, while SH3 domains recognize a PxxP motif and additional residues that mediate binding specificity.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1016/0968-0004(94)90129-5DOIArticle
ORCID:
AuthorORCID
Baltimore, David0000-0001-8723-8190
Additional Information:© 1994 Published by Elsevier Ltd. We would like to thank our colleagues J. Groffen, G. Kruh, A. M. Pendergast and J. Y. J. Wang for contributing information before publication. We are especially grateful to A. Musacchio for the generous gift of Fig. 2, and to D. Cowburn and B. Knudsen for comments on the manuscript.
Issue or Number:11
Record Number:CaltechAUTHORS:20200513-074221409
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20200513-074221409
Official Citation:Stephan M. Feller, Ruibao Ren, Hidesaburo Hanafusa, David Baltimore, SH2 and SH3 domains as molecular adhesives: the interactions of Crk and Abl, Trends in Biochemical Sciences, Volume 19, Issue 11, 1994, Pages 453-458, ISSN 0968-0004, https://doi.org/10.1016/0968-0004(94)90129-5. (http://www.sciencedirect.com/science/article/pii/0968000494901295)
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:103164
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:13 May 2020 15:42
Last Modified:13 May 2020 15:42

Repository Staff Only: item control page