Lu, Zhe and Fu, Gregory C. (2010) Alkyl-Alkyl Suzuki Cross-Coupling of Unactivated Secondary Alkyl Chlorides. Angewandte Chemie International Edition, 49 (37). pp. 6676-6678. ISSN 1433-7851. PMCID PMC3073318. doi:10.1002/anie.201003272. https://resolver.caltech.edu/CaltechAUTHORS:20200513-100146935
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Abstract
No such thing as a problem substrate! In a reaction designed specifically for the title substrates C-C coupling with alkyl boranes occurred in good yield at room temperature with commercially available catalyst components (see scheme). This versatile method is also suitable for Suzuki reactions of secondary and primary alkyl bromides and iodides, as well as primary alkyl chlorides.
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| Additional Information: | © 2010 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim. Received: May 30, 2010; Published online: August 16, 2010. Support has been provided by the National Institutes of Health (National Institute of General Medical Sciences, grant R01-GM62871), Eli Lilly (fellowship to Z.L.), the Martin Family Society of Fellows for Sustainability (fellowship to Z.L.), Merck Research Laboratories, and Novartis. We thank Dr. Bunnai Saito for preliminary studies and Dr. Jeffrey H. Simpson for assistance with NMR spectroscopy. | ||||||||||||
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| Subject Keywords: | alkyl halides; boron; cross‐coupling; homogeneous catalysis; nickel | ||||||||||||
| Issue or Number: | 37 | ||||||||||||
| PubMed Central ID: | PMC3073318 | ||||||||||||
| DOI: | 10.1002/anie.201003272 | ||||||||||||
| Record Number: | CaltechAUTHORS:20200513-100146935 | ||||||||||||
| Persistent URL: | https://resolver.caltech.edu/CaltechAUTHORS:20200513-100146935 | ||||||||||||
| Official Citation: | Lu, Z. and Fu, G. (2010), Alkyl–Alkyl Suzuki Cross‐Coupling of Unactivated Secondary Alkyl Chlorides. Angewandte Chemie International Edition, 49: 6676-6678. doi:10.1002/anie.201003272 | ||||||||||||
| Usage Policy: | No commercial reproduction, distribution, display or performance rights in this work are provided. | ||||||||||||
| ID Code: | 103171 | ||||||||||||
| Collection: | CaltechAUTHORS | ||||||||||||
| Deposited By: | Tony Diaz | ||||||||||||
| Deposited On: | 13 May 2020 17:39 | ||||||||||||
| Last Modified: | 16 Nov 2021 18:19 |
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