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Functional Analysis of the TAN-1 Gene, a Human Homolog of Drosophila Notch

Aster, J. and Pear, W. and Hasserjian, R. and Erba, H. and Davi, F. and Luo, B. and Scott, M. and Baltimore, D. and Sklar, J. (1994) Functional Analysis of the TAN-1 Gene, a Human Homolog of Drosophila Notch. Cold Spring Harbor Symposia on Quantitative Biology, 59 . pp. 125-136. ISSN 0091-7451. https://resolver.caltech.edu/CaltechAUTHORS:20200513-131711374

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Abstract

The TAN-1 gene was originally discovered at the breakpoint of a recurrent (7;9)(q34;q34.3) chromosomal translocation found in a subset of human T-lymphoblastic leukemias (Reynolds et al. 1987; Smith et al. 1988; Ellisen et al. 1991). This translocation joins roughly the 3′ half of TAN-1 head-to-head with the 3′ portion of the β T-cell-receptor gene (TCRB) beginning at the 5′ boundary of one or the other J segment. Intact TAN-1 is normally transcribed into an 8.2-kb transcript that is present in many tissues, most abundantly in developing thymus and spleen (Ellisen et al. 1991). This tissue distribution and the apparent involvement of an altered version of the gene in T-cell cancers have suggested that TAN-1 normally has some special function in lymphocytes or their precursors.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1101/sqb.1994.059.01.016DOIArticle
ORCID:
AuthorORCID
Baltimore, D.0000-0001-8723-8190
Additional Information:© 1994 Cold Spring Harbor Laboratory Press.
Record Number:CaltechAUTHORS:20200513-131711374
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20200513-131711374
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:103179
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:13 May 2020 22:32
Last Modified:13 May 2020 22:32

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