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Functional Analysis of the TAN-1 Gene, a Human Homolog of Drosophila Notch

Aster, J. and Pear, W. and Hasserjian, R. and Erba, H. and Davi, F. and Luo, B. and Scott, M. and Baltimore, D. and Sklar, J. (1994) Functional Analysis of the TAN-1 Gene, a Human Homolog of Drosophila Notch. Cold Spring Harbor Symposia on Quantitative Biology, 59 . pp. 125-136. ISSN 0091-7451.

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The TAN-1 gene was originally discovered at the breakpoint of a recurrent (7;9)(q34;q34.3) chromosomal translocation found in a subset of human T-lymphoblastic leukemias (Reynolds et al. 1987; Smith et al. 1988; Ellisen et al. 1991). This translocation joins roughly the 3′ half of TAN-1 head-to-head with the 3′ portion of the β T-cell-receptor gene (TCRB) beginning at the 5′ boundary of one or the other J segment. Intact TAN-1 is normally transcribed into an 8.2-kb transcript that is present in many tissues, most abundantly in developing thymus and spleen (Ellisen et al. 1991). This tissue distribution and the apparent involvement of an altered version of the gene in T-cell cancers have suggested that TAN-1 normally has some special function in lymphocytes or their precursors.

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Baltimore, D.0000-0001-8723-8190
Additional Information:© 1994 Cold Spring Harbor Laboratory Press.
Record Number:CaltechAUTHORS:20200513-131711374
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ID Code:103179
Deposited By: Tony Diaz
Deposited On:13 May 2020 22:32
Last Modified:13 May 2020 22:32

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