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The candidate proto-oncogene bcl-3 encodes a transcriptional coactivator that activates through NF-κB p50 homodimers

Fujita, Takashi and Nolan, Garry P. and Liou, Hsiou-Chi and Scott, Martin L. and Baltimore, David (1993) The candidate proto-oncogene bcl-3 encodes a transcriptional coactivator that activates through NF-κB p50 homodimers. Genes and Development, 7 (7b). pp. 1354-1363. ISSN 0890-9369.

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The candidate proto-oncogene bcl-3 encodes a protein that shares structural features with IκB-α and other proteins that bind to members of the Rel protein family. Here, we show that in contrast to the inhibitory activity of IκB-α, the bcl-3 gene product superactivates NF-κB p50 homodimer-mediated gene expression both in vivo and in vitro. BCL-3 protein can, as well, selectively associate with p50 homodimers in the presence of DNA containing a κB motif. These results strongly suggest that BCL-3 can act as a transcriptional coactivator, acting through DNA-bound p50 homodimers.

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Baltimore, David0000-0001-8723-8190
Additional Information:© 1993 by Cold Spring Harbor Press. Received January 8, 1993; revised version accepted May 21, 1993. This research was supported by fellowships from the Human Frontier Science Program (T.F.), the Leukemia Society (G.P.N.), the Cancer Research Institute (H.-C.L.), the National Institutes of Health (NIH) (CA51462) (M.L.S.), and NIH grant GM39458-04 (D.B.) T.F. is grateful for encouragement by workers in the Baltimore laboratory, the Taniguchi laboratory, and the Department of Tumor Cell Biology (Tokyo). The publication costs of this article were defrayed in part by payment of page charges. This article must therefore be hereby marked "advertisement" in accordance with 18 USC section 1734 solely to indicate this fact.
Funding AgencyGrant Number
Human Frontier Science ProgramUNSPECIFIED
Leukemia Society of AmericaUNSPECIFIED
Cancer Research InstituteUNSPECIFIED
Subject Keywords:NF-κB; p50; IκB; transcription; coactivator
Issue or Number:7b
Record Number:CaltechAUTHORS:20200513-135823678
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:103182
Deposited By: Tony Diaz
Deposited On:13 May 2020 22:27
Last Modified:13 May 2020 22:27

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