Nolan, Garry P. and Baltimore, David (1992) The inhibitory ankyrin and activator Rel proteins. Current Opinion in Genetics and Development, 2 (2). pp. 211-220. ISSN 0959-437X. doi:10.1016/s0959-437x(05)80276-x. https://resolver.caltech.edu/CaltechAUTHORS:20200514-155839664
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Abstract
The gene families encoding the proteins NF-κB, c-Rel and Dorsal, in conjunction with their respective inhibitors IκB, pp40, and Cactus, achieve specificity in gene regulation by means of common principles. The related activities of NF-κB and Dorsal are mediated by heterodimeric or homodimeric complexes of proteins containing the conserved dimerization and DNA-binding domain termed Rel. The IκBs and Cactus, which share a core series of structural repeats termed ankyrin, inhibit cognate activators through differential interactions with the Rel-homology domain. Together, the inhibitory ankyrin proteins and their cognate Rel dimers probably define specific signalling pathways able to activate specific gene expression. Both gene families include proto-oncogenes, thus broadly implicating Rel/IκB in the control of both normal gene expression and the abberant gene expression that makes cells cancerous.
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Additional Information: | © 1992 Published by Elsevier Ltd. We thank T Fujita, H Liou, M Scott, E Spanopoulou and other members of D Baltimore's laboratory for critical comment on this manuscript. We are especially grateful to colleagues for discussions or for the sharing of data with us prior to publications: A Baldwin, P Baeuerle, A Bergmann, K Bhatia, V Blank, R Bravo, T Fujita, H Liou, R Geissler, S Ghosh, L Kerr, C Duckett, J Inoue, A Israel, L Herzenberg, L Herzenberg, S Kidd, G Nabel, K Ozato, D Stein, I Vemaa and C Nüsslein-Volhard. | ||||||
Issue or Number: | 2 | ||||||
DOI: | 10.1016/s0959-437x(05)80276-x | ||||||
Record Number: | CaltechAUTHORS:20200514-155839664 | ||||||
Persistent URL: | https://resolver.caltech.edu/CaltechAUTHORS:20200514-155839664 | ||||||
Official Citation: | Garry P. Nolan, David Baltimore, The inhibitory ankyrin and activator Rel proteins, Current Opinion in Genetics & Development, Volume 2, Issue 2, 1992, Pages 211-220, ISSN 0959-437X, https://doi.org/10.1016/S0959-437X(05)80276-X. (http://www.sciencedirect.com/science/article/pii/S0959437X0580276X) | ||||||
Usage Policy: | No commercial reproduction, distribution, display or performance rights in this work are provided. | ||||||
ID Code: | 103217 | ||||||
Collection: | CaltechAUTHORS | ||||||
Deposited By: | Tony Diaz | ||||||
Deposited On: | 14 May 2020 23:41 | ||||||
Last Modified: | 16 Nov 2021 18:19 |
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