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The inhibitory ankyrin and activator Rel proteins

Nolan, Garry P. and Baltimore, David (1992) The inhibitory ankyrin and activator Rel proteins. Current Opinion in Genetics and Development, 2 (2). pp. 211-220. ISSN 0959-437X. https://resolver.caltech.edu/CaltechAUTHORS:20200514-155839664

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Abstract

The gene families encoding the proteins NF-κB, c-Rel and Dorsal, in conjunction with their respective inhibitors IκB, pp40, and Cactus, achieve specificity in gene regulation by means of common principles. The related activities of NF-κB and Dorsal are mediated by heterodimeric or homodimeric complexes of proteins containing the conserved dimerization and DNA-binding domain termed Rel. The IκBs and Cactus, which share a core series of structural repeats termed ankyrin, inhibit cognate activators through differential interactions with the Rel-homology domain. Together, the inhibitory ankyrin proteins and their cognate Rel dimers probably define specific signalling pathways able to activate specific gene expression. Both gene families include proto-oncogenes, thus broadly implicating Rel/IκB in the control of both normal gene expression and the abberant gene expression that makes cells cancerous.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1016/s0959-437x(05)80276-xDOIArticle
ORCID:
AuthorORCID
Baltimore, David0000-0001-8723-8190
Additional Information:© 1992 Published by Elsevier Ltd. We thank T Fujita, H Liou, M Scott, E Spanopoulou and other members of D Baltimore's laboratory for critical comment on this manuscript. We are especially grateful to colleagues for discussions or for the sharing of data with us prior to publications: A Baldwin, P Baeuerle, A Bergmann, K Bhatia, V Blank, R Bravo, T Fujita, H Liou, R Geissler, S Ghosh, L Kerr, C Duckett, J Inoue, A Israel, L Herzenberg, L Herzenberg, S Kidd, G Nabel, K Ozato, D Stein, I Vemaa and C Nüsslein-Volhard.
Issue or Number:2
Record Number:CaltechAUTHORS:20200514-155839664
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20200514-155839664
Official Citation:Garry P. Nolan, David Baltimore, The inhibitory ankyrin and activator Rel proteins, Current Opinion in Genetics & Development, Volume 2, Issue 2, 1992, Pages 211-220, ISSN 0959-437X, https://doi.org/10.1016/S0959-437X(05)80276-X. (http://www.sciencedirect.com/science/article/pii/S0959437X0580276X)
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:103217
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:14 May 2020 23:41
Last Modified:14 May 2020 23:41

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