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Rel-associated pp40: an inhibitor of the rel family of transcription factors

Davis, Nathan and Ghosh, Sankar and Simmons, Daniel L. and Tempst, Paul and Liou, Hsiou-Chi and Baltimore, David and Bose, Henry R., Jr. (1991) Rel-associated pp40: an inhibitor of the rel family of transcription factors. Science, 253 (5025). pp. 1268-1271. ISSN 0036-8075. doi:10.1126/science.1891714.

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The Rel-associated protein pp40 is functionally related to IκB, an inhibitor of the transcription factor NF-κB. Purified pp40 inhibits the DNA binding activity of the NF-κB protein complex (p50:p65 heterodimers), p50:c-Rel heteromers, and c-Rel homodimers. The sequence of the complementary DNA encoding pp40 revealed similarity to the gene encoding MAD-3, a protein with mammalian IκB-like activity. Protein sequencing of IκB purified from rabbit lung confirmed that MAD-3 encodes a protein similar to IκB. The sequence similarity between MAD-3 and pp40 includes a casein kinase II and consensus tyrosine phosphorylation site, as well as five repeats of a sequence found in the human erythrocyte protein ankyrin. These results suggest that rel-related transcription factors, which are capable of cytosolic to nuclear translocation, may be held in the cytosol by interaction with related cytoplasmic anchor molecules.

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Baltimore, David0000-0001-8723-8190
Additional Information:© 1991 American Association for the Advancement of Science. Received 3 July 1991; accepted 31 July 1991. The first two authors contributed equally to this work. We thank I. Verma for the c-rel done, M. Gifford for excellent technical help, M. Schlissel, M. Feinberg, and E. Spanopoulou for reviewing the manuscript, and X.-H. Sun for help and stimulating discussions. Supported by an NIH training grant CA09583 (N.D.), postdoctoral fellowships from Irvington Institute for Medical Research (S.G.) and the Cancer Research Institute (H.C.L.), NIH grants Ca33192 and Ca2616 (D.B. and H.R.B.) and the Bireley Foundation (D.S.)
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Irvington Institute for Medical ResearchUNSPECIFIED
Cancer Research InstituteUNSPECIFIED
Bireley FoundationUNSPECIFIED
Issue or Number:5025
Record Number:CaltechAUTHORS:20200514-161356013
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Official Citation:Rel-associated pp40: an inhibitor of the rel family of transcription factors. BY N DAVIS, S GHOSH, DL SIMMONS, P TEMPST, HC LIOU, D BALTIMORE, HR BOSE JR. SCIENCE 13 SEP 1991: 1268-1271; doi: 10.1126/science.1891714
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:103219
Deposited By: Tony Diaz
Deposited On:14 May 2020 23:42
Last Modified:16 Nov 2021 18:19

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