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Stereochemical issues in studies of ion channel proteins

Dougherty, Dennis A. (1998) Stereochemical issues in studies of ion channel proteins. Chirality, 10 (1-2). pp. 8-13. ISSN 0899-0042. doi:10.1002/chir.3.

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Studies of ion channel proteins present many special challenges, including the potential for novel stereochemical phenomena. Here we describe several examples in which modern studies of ion channels have involved or made use of stereochemistry.

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Dougherty, Dennis A.0000-0003-1464-2461
Additional Information:© 1998 Wiley-Liss, Inc. Received for publication 11 November 1996; Accepted 4 April 1997. Contract grant sponsor: National Institutes of Health; Contract grant number: NS 34407. Ion channels may seem far afield from molecular propellers and other systems we thought about in the Mislow group. Still, the most important thing one can learn from Kurt Mislow is how to think and act like a scientist, and we hope that we will, on occasion, be able to bring the depth of insight and rigor of analysis so strongly associated with Mislow’s work to this fascinating area. I thank the many outstanding students and postdocs who have worked on these projects. Especially critical to the stereochemical studies described here were Scott Silverman and Pat Kearney. I also thank Henry Lester for his patience in helping a group of chemists learn the ion channel field. This work was supported by the National Institutes of Health (NS 34407).
Funding AgencyGrant Number
NIHNS 34407
Subject Keywords:stereochemistry; ion channel proteins; nAChR; K+ channels; subunit arrangement
Issue or Number:1-2
Record Number:CaltechAUTHORS:20200515-135615396
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Official Citation:Dougherty, D.A. (1998), Stereochemical issues in studies of ion channel proteins. Chirality, 10: 8-13. doi:10.1002/chir.3
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:103243
Deposited By: Tony Diaz
Deposited On:15 May 2020 21:09
Last Modified:16 Nov 2021 18:19

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