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Bioinspired Disordered Flexible Metasurfaces for Human Tear Analysis Using Broadband Surface-Enhanced Raman Scattering

Narasimhan, Vinayak and Siddique, Radwanul Hasan and Park, Haeri and Choo, Hyuck (2020) Bioinspired Disordered Flexible Metasurfaces for Human Tear Analysis Using Broadband Surface-Enhanced Raman Scattering. ACS Omega, 5 (22). pp. 12915-12922. ISSN 2470-1343. PMCID PMC7288574. https://resolver.caltech.edu/CaltechAUTHORS:20200519-075614206

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Abstract

Flexible surface-enhanced Raman scattering (SERS) has received attention as a means to move SERS-based broadband biosensing from bench to bedside. However, traditional flexible periodic nano-arrangements with sharp plasmonic resonances or their random counterparts with spatially varying uncontrollable enhancements are not reliable for practical broadband biosensing. Here, we report bioinspired quasi-(dis)ordered nanostructures presenting a broadband yet tunable application-specific SERS enhancement profile. Using simple, scalable biomimetic fabrication, we create a flexible metasurface (flex-MS) of quasi-(dis)ordered metal–insulator–metal (MIM) nanostructures with spectrally variable, yet spatially controlled electromagnetic hotspots. The MIM is designed to simultaneously localize the electromagnetic signal and block background Raman signals from the underlying polymeric substrate—an inherent problem of flexible SERS. We elucidate the effect of quasi-(dis)ordering on broadband tunable SERS enhancement and employ the flex-MS in a practical broadband SERS demonstration to detect human tear uric acid within its physiological concentration range (25–150 μM). The performance of the flex-MS toward noninvasively detecting whole human tear uric acid levels ex vivo is in good agreement with a commercial enzyme-based assay.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1021/acsomega.0c00677DOIArticle
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7288574UNSPECIFIEDUNSPECIFIED
ORCID:
AuthorORCID
Narasimhan, Vinayak0000-0003-4165-402X
Siddique, Radwanul Hasan0000-0001-7494-5857
Choo, Hyuck0000-0002-8903-7939
Additional Information:© 2020 American Chemical Society. This is an open access article published under an ACS AuthorChoice License, which permits copying and redistribution of the article or any adaptations for non-commercial purposes. Received: February 14, 2020; Accepted: May 6, 2020; Published: May 18, 2020. The authors acknowledge the financial support provided by the SAMSUNG Global Research Outreach (GRO) program. The authors are also thankful for the support and resources provided by the Kavli Nanoscience Institute at Caltech. Author Contributions: V.N., R.H.S., and H.C. conceived the study. V.N., R.H.S., and H.P. performed the necessary simulations and experiments under the supervision of H.C. The manuscript was written through contributions of all the authors. SAMSUNG Global Research Outreach (GRO) program. The authors declare no competing financial interest.
Group:Kavli Nanoscience Institute
Funders:
Funding AgencyGrant Number
SAMSUNG Global Research OutreachUNSPECIFIED
Issue or Number:22
PubMed Central ID:PMC7288574
Record Number:CaltechAUTHORS:20200519-075614206
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20200519-075614206
Official Citation:Bioinspired Disordered Flexible Metasurfaces for Human Tear Analysis Using Broadband Surface-Enhanced Raman Scattering. Vinayak Narasimhan, Radwanul Hasan Siddique, Haeri Park, and Hyuck Choo. ACS Omega 2020 5 (22), 12915-12922; DOI: 10.1021/acsomega.0c00677
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:103298
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:19 May 2020 16:45
Last Modified:15 Jul 2020 20:52

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