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Long-Range Mechanical Force Enables Self-Assembly of Epithelial Tubules

Guo, Chin-Lin and Ouyang, Mingxing and Yu, Jiun-Yann (2012) Long-Range Mechanical Force Enables Self-Assembly of Epithelial Tubules. In: Mechanics of Biological Systems and Materials. Conference Proceedings of the Society for Experimental Mechanics Series. Vol.5. Springer , New York, NY, pp. 15-21. ISBN 978-1-4614-4426-8. https://resolver.caltech.edu/CaltechAUTHORS:20200519-144050973

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Abstract

Spatiotemporal coordination of cell positioning and differentiation is critical in morphogenesis. Loss of coordination is often a hallmark of tissue abnormality and tumorigenesis. Recent studies indicate the importance of mechanical force in morphogenesis such as tubular pattern formation. However, how cells coordinate mechanical interactions between each other and with extracellular matrix (ECM), to initiate, regulate, or maintain long-range tubular patterns is unclear. Using a two-step process to quantitatively control cell-ECM interaction, we find that epithelial cells, in response to a fine-tuned percentage of type I collagen (COL) in ECM, develop various patterns resembling those observed in tubulo-lobular organs. In contrast with conventional thought, these patterns arise through mechanical interactions between cells, but not through gradients of diffusible biochemical factors. Remarkably, a very large spatial scale of tubular patterns is found by cell-COL self-organization in the liquid phase, leading to the formation of long-range (~1 cm) epithelial tubule. Our results suggest a potential mechanism cells can use to form and coordinate long-range tubular patterns, independent of those controlled by diffusible biochemical factors, and provide a new strategy to engineer/regenerate tubular organs.


Item Type:Book Section
Related URLs:
URLURL TypeDescription
https://doi.org/10.1007/978-1-4614-4427-5_3DOIArticle
https://rdcu.be/b4g9iPublisherFree ReadCube access
Additional Information:© 2013 The Society for Experimental Mechanics, Inc. First Online: 10 September 2012.
Subject Keywords:Mechanical force; Long-range; Extracellular matrix; Spatial pattern
Series Name:Conference Proceedings of the Society for Experimental Mechanics Series
Record Number:CaltechAUTHORS:20200519-144050973
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20200519-144050973
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:103327
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:19 May 2020 21:49
Last Modified:19 May 2020 21:49

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