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Pattern Formation in Sea Urchin Endomesoderm as Instructed by Gene Regulatory Network Topologies

Peter, Isabelle S. and Davidson, Eric H. (2012) Pattern Formation in Sea Urchin Endomesoderm as Instructed by Gene Regulatory Network Topologies. In: Pattern Formation in Morphogenesis: Problems and Mathematical Issues. Springer Proceedings in Mathematics. No.15. Springer , Berlin, pp. 75-92. ISBN 978-3-642-20163-9.

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Animals consist of body parts which are spatially discrete functional units. The spatial separation of these body parts and the diversification of their function and structure are developmentally controlled by gene regulatory networks. The transcription factors and signaling molecules which participate in the spatial organization of a developing organism are components of these networks. The causal linkages in the network consist of the regulatory interactions of each factor with its target genes. Interactions among different regulatory genes are responsible for forming specific spatial patterns of gene expression. The architecture of these regulatory interactions and how they instruct the formation of specific spatial domains is directly determined by the genomic sequence. In the sea urchin embryo, many such spatial domains are established early in development. A well-characterized gene regulatory network underlies the specification of endodermal and mesodermal regulatory domains in this embryo. We review multiple examples which reveal the causal logic underlying genomic control strategies for pattern formation during sea urchin embryogenesis.

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Peter, Isabelle S.0000-0003-3685-3147
Additional Information:© 2013 Springer-Verlag Berlin Heidelberg. First Online: 05 August 2012. We are pleased to acknowledge support from NIH Grant HD037105.
Funding AgencyGrant Number
Subject Keywords:Regulatory Interaction; Gene Regulatory Network; Gene Regulatory Network Model; Upstream Transcription Factor; Larval Skeleton
Series Name:Springer Proceedings in Mathematics
Issue or Number:15
Record Number:CaltechAUTHORS:20200519-154017901
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:103332
Deposited By: Tony Diaz
Deposited On:19 May 2020 22:56
Last Modified:16 Nov 2021 18:20

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