CaltechAUTHORS
  A Caltech Library Service

Sustained release of human growth hormone from in situ forming hydrogels using self-assembly of fluoroalkyl-ended poly(ethylene glycol)

Tae, Giyoong and Kornfield, Julia A. and Hubbell, Jeffrey A. (2005) Sustained release of human growth hormone from in situ forming hydrogels using self-assembly of fluoroalkyl-ended poly(ethylene glycol). Biomaterials, 26 (25). pp. 5259-5266. ISSN 0142-9612. https://resolver.caltech.edu/CaltechAUTHORS:20200519-170818018

Full text is not posted in this repository. Consult Related URLs below.

Use this Persistent URL to link to this item: https://resolver.caltech.edu/CaltechAUTHORS:20200519-170818018

Abstract

Poly(ethylene glycol)s modified with fluorocarbon end groups are capable of in situ transition from an injectable liquid to a viscoelastic hydrogel by hydrophobic interaction of the end groups; this class of materials is useful for a variety of biomedical applications, including sustained protein release. The hydrogel state can be transformed into an injectable state by the addition of a toxicologically acceptable organic solvent, such as N-methyl pyrrolidone; after injection, this solution quickly returns to a gel state by diffusion of the water-miscible organic solvent into the surrounding environment. In vitro characterization of sustained release of human growth hormone (hGH) using this injectable depot shows that hGH remains stable inside the hydrogel formed, and demonstrates more than 2 weeks of prolonged release of hGH complexed with Zn²⁺ ions without protein aggregation or initial burst.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1016/j.biomaterials.2005.01.042DOIArticle
ORCID:
AuthorORCID
Tae, Giyoong0000-0001-9513-8093
Kornfield, Julia A.0000-0001-6746-8634
Hubbell, Jeffrey A.0000-0003-0276-5456
Additional Information:© 2005 Elsevier Ltd. Received 14 September 2004; accepted 17 January 2005. We thank the National Hormone & Pituitary Program of National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) and A.F. Parlow for providing human growth hormone. We gratefully acknowledge support from the Keck Discovery Fund and the Center for the Science and Engineering of Materials (an NSF MRSEC DMR-0080065) at Caltech.
Funders:
Funding AgencyGrant Number
W. M. Keck FoundationUNSPECIFIED
NSFDMR-0080065
Issue or Number:25
Record Number:CaltechAUTHORS:20200519-170818018
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20200519-170818018
Official Citation:Tae G, Kornfield JA, Hubbell JA. Sustained release of human growth hormone from in situ forming hydrogels using self-assembly of fluoroalkyl-ended poly(ethylene glycol). Biomaterials. 2005; 26(25): 5259‐5266. doi:10.1016/j.biomaterials.2005.01.042
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:103334
Collection:CaltechAUTHORS
Deposited By: Rebecca Minjarez
Deposited On:20 May 2020 15:40
Last Modified:20 May 2020 15:40

Repository Staff Only: item control page