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Collective Migrations of Drosophila Embryonic Trunk and Caudal Mesoderm-Derived Muscle Precursor Cells

Sun, Jingjing and Macabenta, Frank and Akos, Zsuzsa and Stathopoulos, Angelike (2020) Collective Migrations of Drosophila Embryonic Trunk and Caudal Mesoderm-Derived Muscle Precursor Cells. Genetics, 215 (2). pp. 297-322. ISSN 0016-6731. PMCID PMC7268997. https://resolver.caltech.edu/CaltechAUTHORS:20200603-130142304

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Abstract

Mesoderm migration in the Drosophila embryo is a highly conserved, complex process that is required for the formation of specialized tissues and organs, including the somatic and visceral musculature. In this FlyBook chapter, we will compare and contrast the specification and migration of cells originating from the trunk and caudal mesoderm. Both cell types engage in collective migrations that enable cells to achieve new positions within developing embryos and form distinct tissues. To start, we will discuss specification and early morphogenetic movements of the presumptive mesoderm, then focus on the coordinate movements of the two subtypes trunk mesoderm and caudal visceral mesoderm, ending with a comparison of these processes including general insights gained through study.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1534/genetics.120.303258DOIArticle
http://www.ncbi.nlm.nih.gov/pmc/articles/pmc7268997/PubMed CentralArticle
ORCID:
AuthorORCID
Sun, Jingjing0000-0002-0603-790X
Macabenta, Frank0000-0002-6583-3244
Akos, Zsuzsa0000-0002-4587-6212
Stathopoulos, Angelike0000-0001-6597-2036
Additional Information:© 2020 by the Genetics Society of America. Manuscript received August 27, 2019; accepted for publication April 17, 2020. We thank Mary Baylies, Manfred Frasch, Volker Hartenstein, Snehalata Kadam, Arno Müller, and Ulrich Tepass, as several of the illustrations in this manuscript were either adapted from or inspired by their work; Carl Thummel and Trudi Schupbach, for their patience during the extended length of time we required to prepare this chapter; the past and present members of the Stathopoulos laboratory; FlyBase; the Bloomington Drosophila Stock Center; the Vienna Drosophila Resource Center; the Kyoto Stock Center; and the fly community. During the preparation of this work, the authors were funded by National Institutes of Health grant R35GM118146 to A.S. and American Heart Association postdoctoral fellowship 18POST34080493 to Z.A.
Funders:
Funding AgencyGrant Number
NIHR35GM118146
American Heart Association18POST34080493
Subject Keywords:adhesion; apicobasal polarity; caudal visceral mesoderm (cvm); collective cell migration; drosophila melanogaster; fgf signaling; mesoderm migration; trunk visceral mesoderm (tvm); flybook
Issue or Number:2
PubMed Central ID:PMC7268997
Record Number:CaltechAUTHORS:20200603-130142304
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20200603-130142304
Official Citation:Collective Migrations of Drosophila Embryonic Trunk and Caudal Mesoderm-Derived Muscle Precursor Cells. Jingjing Sun, Frank Macabenta, Zsuzsa Akos and Angelike Stathopoulos. GENETICS June 1, 2020 vol. 215 no. 2 297-322; https://doi.org/10.1534/genetics.120.303258
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:103671
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:03 Jun 2020 20:12
Last Modified:06 Aug 2020 18:42

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