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Nanotechnology and cancer

Heath, James R. and Davis, Mark E. (2008) Nanotechnology and cancer. Annual Review of Medicine, 59 . pp. 251-265. ISSN 0066-4219. PMCID PMC3706454. http://resolver.caltech.edu/CaltechAUTHORS:HEAarm08

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Abstract

The biological picture of cancer is rapidly advancing from models built from phenomenological descriptions to network models derived from systems biology, which can capture the evolving pathophysiology of the disease at the molecular level. The translation of this (still academic) picture into a clinically relevant framework can be enabling for the war on cancer, but it is a scientific and technological challenge. In this review, we discuss emerging in vitro diagnostic technologies and therapeutic approaches that are being developed to handle this challenge. Our discussion of in vitro diagnostics is guided by the theme of making large numbers of measurements accurately, sensitively, and at very low cost. We discuss diagnostic approaches based on microfluidics and nanotechnology. We then review the current state of the art of nanoparticle-based therapeutics that have reached the clinic. The goal of the presentation is to identify nanotherapeutic strategies that are designed to increase efficacy while simultaneously minimizing the toxic side effects commonly associated with cancer chemotherapies.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1146/annurev.med.59.061506.185523DOIArticle
http://arjournals.annualreviews.org/doi/abs/10.1146/annurev.med.59.061506.185523PublisherArticle
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3706454/PubMed CentralArticle
ORCID:
AuthorORCID
Heath, James R.0000-0001-5356-4385
Additional Information:"Reprinted, with permission, from the Annual Review of Medicine, Volume 59 copyright 2008 by Annual Reviews, www.annualreviews.org" First published online as a Review in Advance on October 15, 2007. Dr. Davis is a consultant and has stock in Calando Pharmaceuticals and Insert Therapeutics. Dr. Heath is on the board of Homestead Clinical Corp., which has obtained licensing rights to the DEAL technology.
Subject Keywords:in vitro diagnostics, cancer therapeutics, nanoparticles, quantum dots, nanowires, microfluidics
PubMed Central ID:PMC3706454
Record Number:CaltechAUTHORS:HEAarm08
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:HEAarm08
Alternative URL:http://dx.doi.org/10.1146/annurev.med.59.061506.185523
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:10368
Collection:CaltechAUTHORS
Deposited By: Lindsay Cleary
Deposited On:01 May 2008
Last Modified:25 Apr 2017 16:50

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