A Caltech Library Service

Fifty years ago: the Neurospora revolution

Horowitz, Norman H. (1991) Fifty years ago: the Neurospora revolution. Genetics, 127 (4). pp. 631-635. ISSN 0016-6731. PMCID PMC1204391.

Full text is not posted in this repository. Consult Related URLs below.

Use this Persistent URL to link to this item:


This year marks the fiftieth anniversary of the publication of one of the pivotal works of modern biology, the first Neurospora paper of BEADLE and TATUM(1941). This brief paper, revolutionary in both its methods and its findings, changed the genetic landscape for all time. Where previously there existed only scattered observations (albeit with some acute insights) on the relation between genetics and biochemistry, this paper established biochemical genetics as an experimental science, one in which progress would no longer be limited by the rarity of mutants with biochemically knowable phenotypes, but where such mutants would be generated at will and where findings could be repeated and hypotheses explored, as in other experimental sciences. This paper was the first in a series of fundamental advances in chemical genetics that by 1953 had bridged the gap between genetics and biochemistry and ushered in the age of molecular biology.

Item Type:Article
Related URLs:
URLURL TypeDescription CentralArticle
Additional Information:© 1991 by the Genetics Society of America.
Issue or Number:4
PubMed Central ID:PMC1204391
Record Number:CaltechAUTHORS:20200608-112838476
Persistent URL:
Official Citation:Fifty years ago: the Neurospora revolution. N H Horowitz GENETICS April 1, 1991 vol. 127 no. 4 631-635
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:103756
Deposited By: George Porter
Deposited On:08 Jun 2020 19:44
Last Modified:08 Jun 2020 19:44

Repository Staff Only: item control page