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Development of Eye Colors in Drosophila: Extraction of the Diffusible Substances Concerned

Thimann, Kenneth V. and Beadle, G. W. (1937) Development of Eye Colors in Drosophila: Extraction of the Diffusible Substances Concerned. Proceedings of the National Academy of Sciences of the United States of America, 23 (3). pp. 143-147. ISSN 0027-8424.

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The development of eye color in Drosophila is known to involve special diffusible substances [1,2]. A genetically vermilion (v) eye will develop wild-type eye color if it is supplied with v+ substance by transplantation or by injection of body fluid of wild type flies. Similarly a genetically cinnabar (cn) eye will develop the color characteristic of wild type if it is supplied with cn+ substance. The present paper summarizes preliminary experiments made to learn something of the nature of the two substances just mentioned. During the course of our studies, Ephrussi and Harnly [3] have shown that pupal fluid can be freed of living cells by freezing in liquid air without destroying the v+ and cn+ substances. Khouvine, Ephrussi and Harnly [4] have shown further that these substances can be extracted from Calliphora pupae with 95 per cent alcohol-ether mixtures and with 95 per cent alcohol but not with pure ether. They conclude that these substances are not proteins or enzymes, a conclusion confirmed by our work.

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Additional Information:Copyright © 1937 by the National Academy of Sciences. Communicated January 25, 1937.
Issue or Number:3
Record Number:CaltechAUTHORS:THIpnas37
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:10379
Deposited By: Archive Administrator
Deposited On:01 May 2008
Last Modified:03 Oct 2019 00:09

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