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Epithelial-to-mesenchymal transition and different migration strategies as viewed from the neural crest

Piacentino, Michael L. and Li, Yuwei and Bronner, Marianne E. (2020) Epithelial-to-mesenchymal transition and different migration strategies as viewed from the neural crest. Current Opinion in Cell Biology, 66 . pp. 43-50. ISSN 0955-0674. https://resolver.caltech.edu/CaltechAUTHORS:20200609-133046051

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Abstract

Epithelial-to-mesenchymal transition (EMT) is a dynamic process that produces migratory cells from epithelial precursors. However, EMT is not binary; rather it results in migratory cells which adopt diverse strategies including collective and individual cell migration to arrive at target destinations. Of the many embryonic cells that undergo EMT, the vertebrate neural crest is a particularly good example which has provided valuable insight into these processes. Neural crest cells from different species often adopt different migratory strategies with collective migration predominating in anamniotes, whereas individual cell migration is more prevalent in amniotes. Here, we will provide a perspective on recent work toward understanding the process of neural crest EMT focusing on how these cells undergo collective and individual cell migration.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1016/j.ceb.2020.05.001DOIArticle
ORCID:
AuthorORCID
Piacentino, Michael L.0000-0003-1773-031X
Li, Yuwei0000-0001-7753-4869
Bronner, Marianne E.0000-0003-4274-1862
Additional Information:© 2020 Elsevier Ltd. Available online 9 June 2020. This review comes from a themed issue on Cell Dynamics; Edited by Diane Barber and Xavier Trepat. The authors would like to acknowledge Dr. Erica Hutchins for valuable discussion. This work was supported by the National Institutes of Health (K99DE029240 to M.L.P., R01DE027538 and R01DE027568 to M.E.B.). The authors apologize to those authors they were unable to cite because of space limitations. Conflict of interest statement: Nothing declared.
Funders:
Funding AgencyGrant Number
NIHK99DE029240
NIHR01DE027538
NIHR01DE027568
Subject Keywords:Developmental biology; Neural Crest; Epithelial-to-mesenchymal transition; Cell migration; Collective migration
Record Number:CaltechAUTHORS:20200609-133046051
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20200609-133046051
Official Citation:Michael L. Piacentino, Yuwei Li, Marianne E. Bronner, Epithelial-to-mesenchymal transition and different migration strategies as viewed from the neural crest, Current Opinion in Cell Biology, Volume 66, 2020, Pages 43-50, ISSN 0955-0674, https://doi.org/10.1016/j.ceb.2020.05.001. (http://www.sciencedirect.com/science/article/pii/S0955067420300648)
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:103799
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:09 Jun 2020 20:35
Last Modified:09 Jun 2020 20:35

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