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Ion Channel Diseases of the Central Nervous System

Li, Ming and Lester, Henry A. (2001) Ion Channel Diseases of the Central Nervous System. CNS Drug Reviews, 7 (2). pp. 214-240. ISSN 1080-563X. PMCID PMC6741647. doi:10.1111/j.1527-3458.2001.tb00196.x. https://resolver.caltech.edu/CaltechAUTHORS:20200612-115646273

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Abstract

In the last decade, advances in molecular genetics and cellular electrophysiology have increased our understanding of ion channel function. A number of diseases termed “channelopathies” have been discovered that are caused by ion channel dysfunction. Channelopathies can be caused by autoimmune, iatrogenic, toxic or genetic mechanisms. Mutations in genes encoding ion channel proteins that disrupt channel function are now the most commonly identified cause of channelopathies, perhaps because gene disruption is readily detected by the methods of molecular genetics. Ion channels are abundant in the central nervous system (CNS), but CNS channelopathies are rare; however, they overlap with some important neurological disorders, such as epilepsy, ataxia, migraine, schizophrenia, Alzheimer's disease and other neurodegenerative diseases. It is possible that more CNS channelopathies will be discovered when additional ion channels are characterized and the complex mechanisms of brain function are better understood. At present, increased knowledge of the identity, structure and function of ion channels is facilitating diagnosis and treatment of many channelopathies.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1111/j.1527-3458.2001.tb00196.xDOIArticle
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6741647/PubMed CentralArticle
ORCID:
AuthorORCID
Lester, Henry A.0000-0002-5470-5255
Additional Information:© 2001 Neva Press. We thank Baljit Khakh and Wenmei Shi for comments. Work in this laboratory is supported by grants from the NIH (DA09121, NS11756, GM29836, MH49176), the University of California Tobacco Related Disease Research Program, and the National Parkinson Foundation. Ming Li holds a National Research Service Award.
Funders:
Funding AgencyGrant Number
NIHDA09121
NIHNS11756
NIHGM29836
NIHMH49176
California Tobacco-Related Disease Research ProgramUNSPECIFIED
National Parkinson FoundationUNSPECIFIED
NIH Predoctoral FellowshipUNSPECIFIED
Subject Keywords:Ion channels – Epilepsy – Ataxia – Schizophrenia — Alzheimer’s disease
Issue or Number:2
PubMed Central ID:PMC6741647
DOI:10.1111/j.1527-3458.2001.tb00196.x
Record Number:CaltechAUTHORS:20200612-115646273
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20200612-115646273
Official Citation:Li, M. and Lester, H.A. (2001), Ion Channel Diseases of the Central Nervous System. CNS Drug Reviews, 7: 214-240. doi:10.1111/j.1527-3458.2001.tb00196.x
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:103873
Collection:CaltechAUTHORS
Deposited By: George Porter
Deposited On:12 Jun 2020 20:30
Last Modified:16 Nov 2021 18:26

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