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Imaging through highly scattering human skulls with ultrasound-modulated optical tomography

Liu, Yan and Cao, Ruizhi and Xu, Jian and Ruan, Haowen and Yang, Changhuei (2020) Imaging through highly scattering human skulls with ultrasound-modulated optical tomography. Optics Letters, 45 (11). pp. 2973-2976. ISSN 0146-9592.

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Advances in human brain imaging technologies are critical to understanding how the brain works and the diagnosis of brain disorders. Existing technologies have different drawbacks, and the human skull poses a great challenge for pure optical and ultrasound imaging technologies. Here we demonstrate the feasibility of using ultrasound-modulated optical tomography, a hybrid technology that combines both light and sound, to image through human skulls. Single-shot off-axis holography was used to measure the field of the ultrasonically tagged light. This Letter paves the way for imaging the brain noninvasively through the skull, with optical contrast and a higher spatial resolution than that of diffuse optical tomography.

Item Type:Article
Related URLs:
URLURL TypeDescription
Liu, Yan0000-0002-5837-4908
Cao, Ruizhi0000-0003-3385-446X
Xu, Jian0000-0002-4743-2471
Ruan, Haowen0000-0002-4917-4509
Yang, Changhuei0000-0001-8791-0354
Additional Information:© 2020 Optical Society of America. Received 10 March 2020; revised 14 April 2020; accepted 20 April 2020; posted 21 April 2020 (Doc. ID 390920); published 20 May 2020. The authors thank Haojiang Zhou, Michelle Cua, Joshua Brake, Jamu Alford, and Adam Marblestone for discussions. Funding: Kernel–Brain Research and Technologies (FS 13520230). Disclosures. C. Yang: (F, P).Other authors declare no conflicts of interest.
Funding AgencyGrant Number
Kernel–Brain Research and TechnologiesFS 13520230
Issue or Number:11
Record Number:CaltechAUTHORS:20200622-104138625
Persistent URL:
Official Citation:Yan Liu, Ruizhi Cao, Jian Xu, Haowen Ruan, and Changhuei Yang, "Imaging through highly scattering human skulls with ultrasound-modulated optical tomography," Opt. Lett. 45, 2973-2976 (2020)
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:103961
Deposited By: George Porter
Deposited On:23 Jun 2020 19:33
Last Modified:23 Jun 2020 19:33

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