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Imaging through highly scattering human skulls with ultrasound-modulated optical tomography

Liu, Yan and Cao, Ruizhi and Xu, Jian and Ruan, Haowen and Yang, Changhuei (2020) Imaging through highly scattering human skulls with ultrasound-modulated optical tomography. Optics Letters, 45 (11). pp. 2973-2976. ISSN 0146-9592. https://resolver.caltech.edu/CaltechAUTHORS:20200622-104138625

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Abstract

Advances in human brain imaging technologies are critical to understanding how the brain works and the diagnosis of brain disorders. Existing technologies have different drawbacks, and the human skull poses a great challenge for pure optical and ultrasound imaging technologies. Here we demonstrate the feasibility of using ultrasound-modulated optical tomography, a hybrid technology that combines both light and sound, to image through human skulls. Single-shot off-axis holography was used to measure the field of the ultrasonically tagged light. This Letter paves the way for imaging the brain noninvasively through the skull, with optical contrast and a higher spatial resolution than that of diffuse optical tomography.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1364/ol.390920DOIArticle
ORCID:
AuthorORCID
Liu, Yan0000-0002-5837-4908
Cao, Ruizhi0000-0003-3385-446X
Xu, Jian0000-0002-4743-2471
Ruan, Haowen0000-0002-4917-4509
Yang, Changhuei0000-0001-8791-0354
Additional Information:© 2020 Optical Society of America. Received 10 March 2020; revised 14 April 2020; accepted 20 April 2020; posted 21 April 2020 (Doc. ID 390920); published 20 May 2020. The authors thank Haojiang Zhou, Michelle Cua, Joshua Brake, Jamu Alford, and Adam Marblestone for discussions. Funding: Kernel–Brain Research and Technologies (FS 13520230). Disclosures. C. Yang: (F, P).Other authors declare no conflicts of interest.
Funders:
Funding AgencyGrant Number
Kernel–Brain Research and TechnologiesFS 13520230
Issue or Number:11
Record Number:CaltechAUTHORS:20200622-104138625
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20200622-104138625
Official Citation:Yan Liu, Ruizhi Cao, Jian Xu, Haowen Ruan, and Changhuei Yang, "Imaging through highly scattering human skulls with ultrasound-modulated optical tomography," Opt. Lett. 45, 2973-2976 (2020)
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:103961
Collection:CaltechAUTHORS
Deposited By: George Porter
Deposited On:23 Jun 2020 19:33
Last Modified:23 Jun 2020 19:33

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