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Nickel-Catalyzed Enantioselective Reductive Cross-Coupling Reactions

Poremba, Kelsey E. and Dibrell, Sara E. and Reisman, Sarah E. (2020) Nickel-Catalyzed Enantioselective Reductive Cross-Coupling Reactions. ACS Catalysis, 10 (15). pp. 8237-8246. ISSN 2155-5435. PMCID PMC7470226. doi:10.1021/acscatal.0c01842.

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Nickel-catalyzed reductive cross-coupling reactions have emerged as powerful methods to join two electrophiles. These reactions have proven particularly useful for the coupling of sec-alkyl electrophiles to form stereogenic centers; however, the development of enantioselective variants remains challenging. In this Perspective, we summarize the progress that has been made toward Ni-catalyzed enantioselective reductive cross-coupling reactions.

Item Type:Article
Related URLs:
URLURL TypeDescription CentralArticle
Poremba, Kelsey E.0000-0002-7446-257X
Dibrell, Sara E.0000-0003-0332-1101
Reisman, Sarah E.0000-0001-8244-9300
Additional Information:© 2020 American Chemical Society. Received: April 24, 2020; Revised: June 19, 2020; Published: June 24, 2020. Fellowship support was provided by the National Science Foundation (graduate research fellowship to K.E.P., S.E.D. Grant No. DGE-1144469). S.E.R. is a Heritage Medical Research Institute Investigator. Financial support from the NIH (R35GM118191-01) is gratefully acknowledged. The authors declare no competing financial interest.
Group:Heritage Medical Research Institute
Funding AgencyGrant Number
NSF Graduate Research FellowshipDGE-1144469
Heritage Medical Research InstituteUNSPECIFIED
Subject Keywords:Nickel-catalysis, enantioselective, reductive cross-coupling, asymmetric catalysis, cross-electrophile coupling
Issue or Number:15
PubMed Central ID:PMC7470226
Record Number:CaltechAUTHORS:20200624-154304037
Persistent URL:
Official Citation:Nickel-Catalyzed Enantioselective Reductive Cross-Coupling Reactions. Kelsey E. Poremba, Sara E. Dibrell, and Sarah E. Reisman. ACS Catalysis 2020 10 (15), 8237-8246; DOI: 10.1021/acscatal.0c01842
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:104020
Deposited By: George Porter
Deposited On:25 Jun 2020 14:04
Last Modified:09 Feb 2022 01:00

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