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Dynamic Selectivity Filters in Ion Channels

Khakh, Baljit S. and Lester, Henry A. (1999) Dynamic Selectivity Filters in Ion Channels. Neuron, 23 (4). pp. 653-658. ISSN 0896-6273. doi:10.1016/s0896-6273(01)80025-8.

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Membrane ion channels contain integral pores that precisely select their permeant ions. This selectivity anchors our concepts of transmembrane signaling in many tissues, including the nervous system. Excitable cells have a rich repertoire of dynamically regulated channels, and this richness and plasticity allows them to use channels beautifully to suit their needs. The selectivity of ion channel pores has generally been viewed as fixed. However, recent studies on disparate classes of ion channels challenge the generality of this idea and show that some ion channels can change their ion selectivity such that normally impermeant ions do in fact permeate under some circumstances. In no case is the mechanism fully understood, but the phenomenon represents both a new functional aspect of ion channels and a suggestion about novel ways in which channels may process information in the nervous system. This review seeks to highlight studies on ion channels that show selectivity changes, point to possible mechanisms, and draw on common themes. We consider P2X and proton-gated channels from the superfamily of transmitter-gated ion channels, Kv and cardiac sodium channels from the superfamily of voltage-gated ion channels, and cyclic nucleotide–gated channels from the family of channels that are gated by intracellular messengers (Figure 1).

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Lester, Henry A.0000-0002-5470-5255
Additional Information:© 1999 Cell Press. Published by Elsevier Under an Elsevier user license. This work was supported by a Wellcome Trust (UK) International Prize Travelling Fellowship and the NIH (NS-11756).
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Issue or Number:4
Record Number:CaltechAUTHORS:20200626-123754307
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Official Citation:Baljit S Khakh, Henry A Lester, Dynamic Selectivity Filters in Ion Channels, Neuron, Volume 23, Issue 4, 1999, Pages 653-658, ISSN 0896-6273,
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:104084
Deposited By: George Porter
Deposited On:26 Jun 2020 21:31
Last Modified:16 Nov 2021 18:28

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