A Caltech Library Service

Catalytic Asymmetric Cross-Couplings of Racemic α-Bromoketones with Arylzinc Reagents

Lundin, Pamela M. and Esquivias, Jorge and Fu, Gregory C. (2008) Catalytic Asymmetric Cross-Couplings of Racemic α-Bromoketones with Arylzinc Reagents. Angewandte Chemie International Edition, 48 (1). pp. 154-156. ISSN 1433-7851. PMCID PMC2790061. doi:10.1002/anie.200804888.

[img] PDF - Accepted Version
See Usage Policy.

[img] PDF - Supplemental Material
See Usage Policy.


Use this Persistent URL to link to this item:


Nickel box : The first catalytic asymmetric method for cross‐coupling arylzinc reagents with α‐bromoketones has been developed (see scheme). This stereoconvergent carbon–carbon bond‐forming process occurs under unusually mild conditions and without activators, thereby allowing the generation of potentially labile tertiary stereocenters.

Item Type:Article
Related URLs:
URLURL TypeDescription CentralArticle
Fu, Gregory C.0000-0002-0927-680X
Additional Information:© 2009 WILEY‐VCH. Received: October 6, 2008. Published online: November 28, 2008. Support has been provided by the National Institutes of Health (National Institute of General Medical Sciences, grant R01‐GM62871), Merck Research Laboratories, Novartis, and the Spanish Department of Science (fellowship for J.E.).
Funding AgencyGrant Number
Merck Research LaboratoriesUNSPECIFIED
Ministerio de Ciencia e Innovación (MCINN)UNSPECIFIED
Subject Keywords:asymmetric catalysis · enantioselectivity · ketones · nickel · zinc
Issue or Number:1
PubMed Central ID:PMC2790061
Record Number:CaltechAUTHORS:20200626-123754710
Persistent URL:
Official Citation:Lundin, P., Esquivias, J. and Fu, G. (2009), Catalytic Asymmetric Cross‐Couplings of Racemic α‐Bromoketones with Arylzinc Reagents. Angew. Chem. Int. Ed., 48: 154-156. doi:10.1002/anie.200804888
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:104087
Deposited By: George Porter
Deposited On:26 Jun 2020 21:02
Last Modified:16 Nov 2021 18:28

Repository Staff Only: item control page