Catalytic Asymmetric Cross-Couplings of Racemic α-Bromoketones with Arylzinc Reagents

Lundin, Pamela M. and Esquivias, Jorge and Fu, Gregory C. (2008) Catalytic Asymmetric Cross-Couplings of Racemic α-Bromoketones with Arylzinc Reagents. Angewandte Chemie International Edition, 48 (1). pp. 154-156. ISSN 1433-7851. PMCID PMC2790061. doi:10.1002/anie.200804888. https://resolver.caltech.edu/CaltechAUTHORS:20200626-123754710

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Abstract

Nickel box : The first catalytic asymmetric method for cross‐coupling arylzinc reagents with α‐bromoketones has been developed (see scheme). This stereoconvergent carbon–carbon bond‐forming process occurs under unusually mild conditions and without activators, thereby allowing the generation of potentially labile tertiary stereocenters.

Item Type:

Article

Related URLs:

URL	URL Type	Description
https://doi.org/10.1002/anie.200804888	DOI	Article
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2790061/	PubMed Central	Article

ORCID:

Author	ORCID
Fu, Gregory C.	0000-0002-0927-680X

Additional Information:

© 2009 WILEY‐VCH. Received: October 6, 2008. Published online: November 28, 2008. Support has been provided by the National Institutes of Health (National Institute of General Medical Sciences, grant R01‐GM62871), Merck Research Laboratories, Novartis, and the Spanish Department of Science (fellowship for J.E.).

Funders:

Funding Agency	Grant Number
NIH	R01‐GM62871
Merck Research Laboratories	UNSPECIFIED
Novartis	UNSPECIFIED
Ministerio de Ciencia e Innovación (MCINN)	UNSPECIFIED

Subject Keywords:

asymmetric catalysis · enantioselectivity · ketones · nickel · zinc

Issue or Number:

PubMed Central ID:

PMC2790061

DOI:

10.1002/anie.200804888

Record Number:

CaltechAUTHORS:20200626-123754710

Persistent URL:

https://resolver.caltech.edu/CaltechAUTHORS:20200626-123754710

Official Citation:

Lundin, P., Esquivias, J. and Fu, G. (2009), Catalytic Asymmetric Cross‐Couplings of Racemic α‐Bromoketones with Arylzinc Reagents. Angew. Chem. Int. Ed., 48: 154-156. doi:10.1002/anie.200804888

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No commercial reproduction, distribution, display or performance rights in this work are provided.

ID Code:

104087

Collection:

CaltechAUTHORS

Deposited By:

George Porter

Deposited On:

26 Jun 2020 21:02

Last Modified:

16 Nov 2021 18:28

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