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The causal role of three frontal cortical areas in grasping

Caprara, I. and Janssen, P. (2020) The causal role of three frontal cortical areas in grasping. . (Unpublished) https://resolver.caltech.edu/CaltechAUTHORS:20200626-145538516

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Abstract

Efficient object grasping requires the continuous control of arm and hand movements based on visual information. Previous studies have identified a network of parietal and frontal areas that is crucial for the visual control of prehension movements. Electrical microstimulation of 3D shape-selective clusters in AIP during fMRI activates areas F5a and 45B, suggesting that these frontal areas may represent important downstream areas for object processing during grasping, but the role of area F5a and 45B in grasping is unknown. To assess their causal role in the frontal grasping network, we reversibly inactivated 45B, F5a and F5p during visually-guided grasping in macaque monkeys. First, we recorded single neuron activity in 45B, F5a and F5p to identify sites with object responses during grasping. Then, we injected muscimol or saline to measure the grasping deficit induced by the temporary disruption of each of these three nodes in the grasping network. The inactivation of all three areas resulted in a significant increase in the grasping time in both animals, with the strongest effect observed in area F5p. These results not only confirm a clear involvement of F5p, but also indicate causal contributions of area F5a and 45B in visually-guided object grasping.


Item Type:Report or Paper (Discussion Paper)
Related URLs:
URLURL TypeDescription
https://doi.org/10.1101/2020.06.25.170126DOIDiscussion Paper
ORCID:
AuthorORCID
Caprara, I.0000-0002-2031-861X
Janssen, P.0000-0002-8463-5577
Additional Information:The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. The authors have declared no competing interest.
Subject Keywords:frontal cortex, grasping, inactivation, macaque, muscimol
Record Number:CaltechAUTHORS:20200626-145538516
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20200626-145538516
Official Citation:The causal role of three frontal cortical areas in grasping Irene Caprara, Peter Janssen bioRxiv 2020.06.25.170126; doi: https://doi.org/10.1101/2020.06.25.170126
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:104098
Collection:CaltechAUTHORS
Deposited By: George Porter
Deposited On:26 Jun 2020 22:23
Last Modified:26 Jun 2020 22:23

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