CaltechAUTHORS
  A Caltech Library Service

The Causal Role of Three Frontal Cortical Areas in Grasping

Caprara, I. and Janssen, P. (2021) The Causal Role of Three Frontal Cortical Areas in Grasping. Cerebral Cortex . ISSN 1047–3211. doi:10.1093/cercor/bhab085. (In Press) https://resolver.caltech.edu/CaltechAUTHORS:20200626-145538516

[img] PDF - Submitted Version
See Usage Policy.

889Kb
[img] Image (PNG) (Fig S1) - Supplemental Material
See Usage Policy.

1291Kb
[img] Image (PNG) (Fig S2) - Supplemental Material
See Usage Policy.

8Mb
[img] MS Word (Supplementary_Figure_Legends) - Supplemental Material
See Usage Policy.

12Kb
[img] Video (MPEG) (supplementary_video_1) - Supplemental Material
See Usage Policy.

7Mb
[img] Video (MPEG) (supplementary_video_2) - Supplemental Material
See Usage Policy.

20Mb

Use this Persistent URL to link to this item: https://resolver.caltech.edu/CaltechAUTHORS:20200626-145538516

Abstract

Efficient object grasping requires the continuous control of arm and hand movements based on visual information. Previous studies have identified a network of parietal and frontal areas that is crucial for the visual control of prehension movements. Electrical microstimulation of 3D shape-selective clusters in AIP during functional magnetic resonance imaging activates areas F5a and 45B, suggesting that these frontal areas may represent important downstream areas for object processing during grasping, but the role of area F5a and 45B in grasping is unknown. To assess their causal role in the frontal grasping network, we reversibly inactivated 45B, F5a, and F5p during visually guided grasping in macaque monkeys. First, we recorded single neuron activity in 45B, F5a, and F5p to identify sites with object responses during grasping. Then, we injected muscimol or saline to measure the grasping deficit induced by the temporary disruption of each of these three nodes in the grasping network. The inactivation of all three areas resulted in a significant increase in the grasping time in both animals, with the strongest effect observed in area F5p. These results not only confirm a clear involvement of F5p, but also indicate causal contributions of area F5a and 45B in visually guided object grasping.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1093/cercor/bhab085DOIArticle
https://doi.org/10.1101/2020.06.25.170126DOIDiscussion Paper
ORCID:
AuthorORCID
Caprara, I.0000-0002-2031-861X
Janssen, P.0000-0002-8463-5577
Additional Information:© The Author(s) 2021. Published by Oxford University Press. This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model). Published: 19 April 2021. We thank Inez Puttemans, Christophe Ulens, Stijn Verstraeten, Piet Kayenbergh, Gerrit Meulemans, Wouter Depuydt and Marc De Paep for technical assistance, and Astrid Hermans and Sara De Pril for administrative support. Conflict of Interest: The authors declare no competing interests. This work was supported by Fonds voorWetenschappelijk Onderzoek Vlaanderen (grants number G.0007.12 and G0A8516N) and KU Leuven (grant number C14/18/100).
Funders:
Funding AgencyGrant Number
Fonds voor Wetenschappelijk Onderzoek (FWO)G.0007.12
Fonds voor Wetenschappelijk Onderzoek (FWO)G0A8516N
Katholieke Universiteit LeuvenC14/18/100
Subject Keywords:frontal cortex, grasping, inactivation, macaque, muscimol
DOI:10.1093/cercor/bhab085
Record Number:CaltechAUTHORS:20200626-145538516
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20200626-145538516
Official Citation:I Caprara, P Janssen, The Causal Role of Three Frontal Cortical Areas in Grasping, Cerebral Cortex, 2021, bhab085, https://doi.org/10.1093/cercor/bhab085
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:104098
Collection:CaltechAUTHORS
Deposited By: George Porter
Deposited On:26 Jun 2020 22:23
Last Modified:19 Apr 2021 21:15

Repository Staff Only: item control page