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Medical micro/nanorobots in complex media

Wu, Zhiguang and Chen, Ye and Mukasa, Daniel and Pak, On Shun and Gao, Wei (2020) Medical micro/nanorobots in complex media. Chemical Society Reviews, 49 (22). pp. 8088-8112. ISSN 0306-0012.

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Medical micro/nanorobots have received tremendous attention over the past decades owing to their potential to be navigated into hard-to-reach tissues for a number of biomedical applications ranging from targeted drug/gene delivery, bio-isolation, detoxification, to nanosurgery. Despite the great promise, the majority of the past demonstrations are primarily under benchtop or in vitro conditions. Many developed micro/nanoscale propulsion mechanisms are based on the assumption of a homogeneous, Newtonian environment, while realistic biological environments are substantially more complex. Moving toward practical medical use, the field of micro/nanorobotics must overcome several major challenges including propulsion through complex media (such as blood, mucus, and vitreous) as well as deep tissue imaging and control in vivo. In this review article, we summarize the recent research efforts on investigating how various complexities in biological environments impact the propulsion of micro/nanoswimmers. We also highlight the emerging technological approaches to enhance the locomotion of micro/nanorobots in complex environments. The recent demonstrations of in vivo imaging, control and therapeutic medical applications of such micro/nanorobots are introduced. We envision that continuing materials and technological innovations through interdisciplinary collaborative efforts can bring us steps closer to the fantasy of “swallowing a surgeon”.

Item Type:Article
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URLURL TypeDescription
Mukasa, Daniel0000-0001-8379-3648
Gao, Wei0000-0002-8503-4562
Additional Information:© 2020 The Royal Society of Chemistry. Submitted 31 Mar 2020; First published 29 Jun 2020. This work was supported by National Science Foundation grants 1931214 (to W. G.), 1830958 and 1931292 (to O. S. P.) and the Donna and Benjamin M. Rosen Bioengineering Center at California Institute of Technology (to W. G.). Conflicts of interest: There are no conflicts to declare.
Group:Rosen Bioengineering Center
Funding AgencyGrant Number
Donna and Benjamin M. Rosen Bioengineering CenterUNSPECIFIED
Issue or Number:22
Record Number:CaltechAUTHORS:20200706-101709396
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Official Citation:Medical micro/nanorobots in complex media. Chem. Soc. Rev., 2020, 49, 8088-8112; DOI: 10.1039/d0cs00309c
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:104223
Deposited By: Tony Diaz
Deposited On:06 Jul 2020 17:23
Last Modified:02 Dec 2020 21:30

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