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Retinotopic organization of human visual cortex mapped with positron-emission tomography

Fox, Peter T. and Miezin, Francis M. and Allman, John M. and Van Essen, David C. and Raichle, Marcus E. (1987) Retinotopic organization of human visual cortex mapped with positron-emission tomography. Journal of Neuroscience, 7 (3). pp. 913-922. ISSN 0270-6474. PMCID PMC6569058. https://resolver.caltech.edu/CaltechAUTHORS:20200708-152146884

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Abstract

The retinotopic organization of primary visual cortex was mapped in normal human volunteers. Positron-emission tomographic measurements of regional cerebral blood flow were employed to detect focal functional brain activation. Oxygen-15-labeled water, delivered by intravenous bolus, was used as the blood flow tracer to allow multiple stimulated- state (n = 5) and control-state (n = 3) measurements to be acquired for each of 7 subjects. Responses were identified by applying a maximum- detection algorithm to subtraction-format images of the stimulus- induced change in cerebral blood flow. Response locales were described using a standardized system of stereotactic coordinates. Changes in stimulus location (macular, perimacular, peripheral, upper-field, lower- field) caused systematic, highly significant changes in response locale within visual cortex. Discrete extrastriate visual responses were also observed.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1523/jneurosci.07-03-00913.1987DOIArticle
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6569058/PubMed CentralArticle
ORCID:
AuthorORCID
Van Essen, David C.0000-0001-7044-4721
Additional Information:© 1987 the Society for Neuroscience. Received June 3, 1986; revised Aug. 25, 1986; accepted Sept. 13, 1986. We thank Lennis Lich and Thomas Hurley for expert technical assistance and Thomas Videen for programming the computer-generated stimuli. This work was supported by NIH Grants NS-06833, HL-13851, NS-07025, NS-0094 (Teacher Investigator Development Award, to P.T.F.), EY03851, and RR-07003, and by a grant from the John Norris Curry Gordon and Jessie Kennicott Gordon Trust.
Funders:
Funding AgencyGrant Number
NIHNS-06833
NIHHL-13851
NIHNS-07025
NIHNS-0094
NIHEY03851
NIHRR-07003
John Norris Curry Gordon and Jessie Kennicott Gordon TrustUNSPECIFIED
Issue or Number:3
PubMed Central ID:PMC6569058
Record Number:CaltechAUTHORS:20200708-152146884
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20200708-152146884
Official Citation:Retinotopic organization of human visual cortex mapped with positron-emission tomography PT Fox, FM Miezin, JM Allman, DC Van Essen, ME Raichle Journal of Neuroscience 1 March 1987, 7 (3) 913-922; DOI: 10.1523/JNEUROSCI.07-03-00913.1987
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:104291
Collection:CaltechAUTHORS
Deposited By: George Porter
Deposited On:08 Jul 2020 22:41
Last Modified:08 Jul 2020 22:41

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