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Beta-band power modulation in the human hippocampus during a reaching task

Del Campo-Vera, Roberto Martin and Gogia, Angad S. and Chen, Kuang-Hsuan and Sebastian, Rinu and Kramer, Daniel R. and Lee, Morgan B. and Peng, Terrance and Tafreshi, Ali and Barbaro, Michael F. and Liu, Charles Y. and Kellis, Spencer and Lee, Brian (2020) Beta-band power modulation in the human hippocampus during a reaching task. Journal of Neural Engineering, 17 (3). Art. No. 036022. ISSN 1741-2552. https://resolver.caltech.edu/CaltechAUTHORS:20200710-083434880

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Abstract

Objective. Characterize the role of the beta-band (13–30 Hz) in the human hippocampus during the execution of voluntary movement. Approach. We recorded electrophysiological activity in human hippocampus during a reach task using stereotactic electroencephalography (SEEG). SEEG has previously been utilized to study the theta band (3–8 Hz) in conflict processing and spatial navigation, but most studies of hippocampal activity during movement have used noninvasive measures such as fMRI. We analyzed modulation in the beta band (13–30 Hz), which is known to play a prominent role throughout the motor system including the cerebral cortex and basal ganglia. We conducted the classic 'center-out' direct-reach experiment with nine patients undergoing surgical treatment for medically refractory epilepsy. Main results. In seven of the nine patients, power spectral analysis showed a statistically significant decrease in power within the beta band (13–30 Hz) during the response phase, compared to the fixation phase, of the center-out direct-reach task using the Wilcoxon signed-rank hypothesis test (p < 0.05). Significance. This finding is consistent with previous literature suggesting that the hippocampus may be involved in the execution of movement, and it is the first time that changes in beta-band power have been demonstrated in the hippocampus using human electrophysiology. Our findings suggest that beta-band modulation in the human hippocampus may play a role in the execution of voluntary movement.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1088/1741-2552/ab937fDOIArticle
ORCID:
AuthorORCID
Gogia, Angad S.0000-0001-8193-1824
Kramer, Daniel R.0000-0003-4551-2977
Tafreshi, Ali0000-0002-8956-3373
Kellis, Spencer0000-0002-5158-1058
Additional Information:© 2020 IOP Publishing Ltd. Received 5 November 2019; Accepted 15 May 2020; Accepted Manuscript online 15 May 2020; Published 12 June 2020.
Group:Tianqiao and Chrissy Chen Institute for Neuroscience
Funders:
Funding AgencyGrant Number
NIHKL2TR001854
Tianqiao and Chrissy Chen Institute for NeuroscienceUNSPECIFIED
Meira and Shaul G. Massry FoundationUNSPECIFIED
Issue or Number:3
Record Number:CaltechAUTHORS:20200710-083434880
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20200710-083434880
Official Citation:Roberto Martin Del Campo-Vera et al 2020 J. Neural Eng. 17 036022
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:104318
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:10 Jul 2020 15:41
Last Modified:10 Jul 2020 15:41

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