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Photoacoustic topography through an ergodic relay for functional imaging and biometric application in vivo

Li, Yang and Li, Lei and Zhu, Liren and Shi, Junhui and Maslov, Konstantin and Wang, Lihong V. (2020) Photoacoustic topography through an ergodic relay for functional imaging and biometric application in vivo. Journal of Biomedical Optics, 25 (7). Art. No. 070501. ISSN 1083-3668. PMCID PMC7347463. https://resolver.caltech.edu/CaltechAUTHORS:20200713-095110805

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Abstract

Significance: Photoacoustic (PA) tomography has demonstrated versatile biomedical applications. However, an array-based PA computed tomography (PACT) system is complex and expensive, whereas a single-element detector-based scanning PA system is too slow to detect some fast biological dynamics in vivo. New PA imaging methods are sought after. Aim: To overcome these limitations, we developed photoacoustic topography through an ergodic relay (PATER), a novel high-speed imaging system with a single-element detector. Approach: PATER images widefield PA signals encoded by the acoustic ergodic relay with a single-laser shot. Results: We applied PATER in vivo to monitor changes in oxygen saturation in a mouse brain and also to demonstrate high-speed matching of vascular patterns for biometric authentication. Conclusions: PATER has achieved a high-speed temporal resolution over a large field of view. Our results suggest that PATER is a promising and economical alternative to PACT for fast imaging.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1117/1.jbo.25.7.070501DOIArticle
http://www.ncbi.nlm.nih.gov/pmc/articles/pmc7347463/PubMed CentralArticle
ORCID:
AuthorORCID
Li, Yang0000-0002-4939-8174
Li, Lei0000-0001-6164-2646
Zhu, Liren0000-0002-6338-9338
Shi, Junhui0000-0002-5741-2781
Maslov, Konstantin0000-0003-3408-8840
Wang, Lihong V.0000-0001-9783-4383
Additional Information:© 2020 The Authors. Published by SPIE under a Creative Commons Attribution 4.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI. Paper 200043LR received Feb. 20, 2020; accepted for publication Jun. 26, 2020; published online Jul. 10, 2020. The authors appreciate the close reading of the manuscript by Professor James Ballard. This work was sponsored by the National Institutes of Health, Grant Nos. R01 CA186567 (NIH Director’s Transformative Research Award), U01 NS090579 (NIH BRAIN Initiative), and U01 NS099717 (NIH BRAIN Initiative). Disclosures: L. V. W. and K. M. have financial interests in Microphotoacoustics, Inc., CalPACT, LLC, and Union Photoacoustic Technologies, Ltd., which did not support this work.
Funders:
Funding AgencyGrant Number
NIHR01 CA186567
NIHU01 NS090579
NIHU01 NS099717
Subject Keywords:photoacoustics; biomedical optics; imaging systems
Issue or Number:7
PubMed Central ID:PMC7347463
Record Number:CaltechAUTHORS:20200713-095110805
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20200713-095110805
Official Citation:Yang Li, Lei Li, Liren Zhu, Junhui Shi, Konstantin Maslov, and Lihong V. Wang "Photoacoustic topography through an ergodic relay for functional imaging and biometric application in vivo," Journal of Biomedical Optics 25(7), 070501 (10 July 2020). https://doi.org/10.1117/1.JBO.25.7.070501
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:104350
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:13 Jul 2020 17:06
Last Modified:22 Jul 2020 19:25

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