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Mitochondrial dynamics during spermatogenesis

Varuzhanyan, Grigor and Chan, David C. (2020) Mitochondrial dynamics during spermatogenesis. Journal of Cell Science, 133 (14). Art. No. jcs235937. ISSN 0021-9533. PMCID PMC7375475. https://resolver.caltech.edu/CaltechAUTHORS:20200717-104855196

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Abstract

Mitochondrial fusion and fission (mitochondrial dynamics) are homeostatic processes that safeguard normal cellular function. This relationship is especially strong in tissues with constitutively high energy demands, such as brain, heart and skeletal muscle. Less is known about the role of mitochondrial dynamics in developmental systems that involve changes in metabolic function. One such system is spermatogenesis. The first mitochondrial dynamics gene, Fuzzy onions (Fzo), was discovered in 1997 to mediate mitochondrial fusion during Drosophila spermatogenesis. In mammals, however, the role of mitochondrial fusion during spermatogenesis remained unknown for nearly two decades after discovery of Fzo. Mammalian spermatogenesis is one of the most complex and lengthy differentiation processes in biology, transforming spermatogonial stem cells into highly specialized sperm cells over a 5-week period. This elaborate differentiation process requires several developmentally regulated mitochondrial and metabolic transitions, making it an attractive model system for studying mitochondrial dynamics in vivo. We review the emerging role of mitochondrial biology, and especially its dynamics, during the development of the male germ line.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1242/jcs.235937DOIArticle
http://www.ncbi.nlm.nih.gov/pmc/articles/pmc7375475/PubMed CentralArticle
ORCID:
AuthorORCID
Varuzhanyan, Grigor0000-0001-6165-0857
Chan, David C.0000-0002-0191-2154
Additional Information:© 2020 Published by The Company of Biologists Ltd. We thank all members of the Chan laboratory for helpful discussions and for comments on the manuscript. The authors declare no competing or financial interests. Work in the laboratory of D.C.C. is funded by the National Institutes of Health (R35GM127147A). Deposited in PMC for release after 12 months.
Funders:
Funding AgencyGrant Number
NIHR35GM127147A
Subject Keywords:Membrane fission, Membrane fusion, Mitochondrial dynamics, Spermatogenesis
Issue or Number:14
PubMed Central ID:PMC7375475
Record Number:CaltechAUTHORS:20200717-104855196
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20200717-104855196
Official Citation:Mitochondrial dynamics during spermatogenesis. Grigor Varuzhanyan, David C. Chan. Journal of Cell Science 2020 133: jcs235937 doi: 10.1242/jcs.235937, Published 16 July 2020
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:104428
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:17 Jul 2020 18:02
Last Modified:06 Aug 2020 18:13

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