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Synaptic organization of cortico-cortical communication in primates

Ashaber, M. and Zalányi, L. and Pálfi, E. and Stuber, I. and Kovács, T. and Roe, A. W. and Friedman, R. M. and Négyessy, L. (2020) Synaptic organization of cortico-cortical communication in primates. European Journal of Neuroscience . ISSN 0953-816X. (In Press) https://resolver.caltech.edu/CaltechAUTHORS:20200720-081014949

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Abstract

In cortical circuitry synaptic communication across areas is based on two types of axon terminals, small and large, with modulatory and driving roles, respectively. In contrast, it is not known whether similar synaptic specializations exist for intra‐areal projections. Using anterograde tracing and three‐dimensional reconstruction by electron microscopy (3D‐EM) we asked if large boutons form synapses in the circuit of somatosensory cortical areas 3b and 1. In contrast to observations in macaque visual cortex, light microscopy showed both small and large boutons not only in inter‐areal pathways, but also in long‐distance intrinsic connections. 3D‐EM showed that correlation of surface and volume provides a powerful tool for classifying cortical endings. Principal component analysis supported this observation and highlighted the significance of the size of mitochondria as a distinguishing feature of bouton type. The larger mitochondrion and higher degree of perforated postsynaptic density associated with large rather than to small boutons support the driver‐like function of large boutons. In contrast to bouton size and complexity, the size of the postsynaptic density appeared invariant across the bouton types. Comparative studies in human supported that size is a major distinguishing factor of bouton type in the cerebral cortex. In conclusion, the driver‐like function of the large endings could facilitate fast dissemination of tactile information within the intrinsic and inter‐areal circuitry of areas 3b and 1.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1111/ejn.14905DOIArticle
ORCID:
AuthorORCID
Ashaber, M.0000-0002-5586-9585
Négyessy, L.0000-0002-4369-0406
Additional Information:© 2020 Wiley. Accepted manuscript online: 12 July 2020.
Subject Keywords:axon terminal; electron microscopy; human; multivariate analyses; Saimiri sciureus; serial section reconstruction; tract tracing
Record Number:CaltechAUTHORS:20200720-081014949
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20200720-081014949
Official Citation:Ashaber, M., Zalányi, L., Pálfi, E., Stuber, I., Kovács, T., Roe, A., Friedman, R. and Négyessy, L. (2020), Synaptic organization of cortico‐cortical communication in primates. Eur J Neurosci. Accepted Author Manuscript. doi:10.1111/ejn.14905
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:104438
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:20 Jul 2020 16:13
Last Modified:20 Jul 2020 16:13

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