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A Review of Default Mode Network Connectivity and Its Association With Social Cognition in Adolescents With Autism Spectrum Disorder and Early-Onset Psychosis

Nair, Aarti and Jolliffe, Morgan and Lograsso, Yong Seuk S. and Bearden, Carrie E. (2020) A Review of Default Mode Network Connectivity and Its Association With Social Cognition in Adolescents With Autism Spectrum Disorder and Early-Onset Psychosis. Frontiers in Psychiatry, 11 . Art. No. 614. ISSN 1664-0640. PMCID PMC7330632. https://resolver.caltech.edu/CaltechAUTHORS:20200720-102909848

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Abstract

Recent studies have demonstrated substantial phenotypic overlap, notably social impairment, between autism spectrum disorder (ASD) and schizophrenia. However, the neural mechanisms underlying the pathogenesis of social impairments across these distinct neuropsychiatric disorders has not yet been fully examined. Most neuroimaging studies to date have focused on adults with these disorders, with little known about the neural underpinnings of social impairments in younger populations. Here, we present a narrative review of the literature available through April 2020 on imaging studies of adolescents with either ASD or early-onset psychosis (EOP), to better understand the shared and unique neural mechanisms of social difficulties across diagnosis from a developmental framework. We specifically focus on functional connectivity studies of the default mode network (DMN), as the most extensively studied brain network relevant to social cognition across both groups. Our review included 29 studies of DMN connectivity in adolescents with ASD (Mean age range = 11.2–21.6 years), and 14 studies in adolescents with EOP (Mean age range = 14.2–24.3 years). Of these, 15 of 29 studies in ASD adolescents found predominant underconnectivity when examining DMN connectivity. In contrast, findings were mixed in adolescents with EOP, with five of 14 studies reporting DMN underconnectivity, and an additional six of 14 studies reporting both under- and over-connectivity of the DMN. Specifically, intra-DMN networks were more frequently underconnected in ASD, but overconnected in EOP. On the other hand, inter-DMN connectivity patterns were mixed (both under- and over-connected) for each group, especially DMN connectivity with frontal, sensorimotor, and temporoparietal regions in ASD, and with frontal, temporal, subcortical, and cerebellar regions in EOP. Finally, disrupted DMN connectivity appeared to be associated with social impairments in both groups, less so with other features distinct to each condition, such as repetitive behaviors/restricted interests in ASD and hallucinations/delusions in EOP. Further studies on demographically well-matched groups of adolescents with each of these conditions are needed to systematically explore additional contributing factors in DMN connectivity patterns such as clinical heterogeneity, pubertal development, and medication effects that would better inform treatment targets and facilitate prediction of outcomes in the context of these developmental neuropsychiatric conditions.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.3389/fpsyt.2020.00614DOIArticle
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7330632PubMed CentralArticle
https://doi.org/10.31234/osf.io/hkcqnDOIDiscussion Paper
ORCID:
AuthorORCID
Nair, Aarti0000-0002-4058-6857
Bearden, Carrie E.0000-0002-8516-923X
Additional Information:© 2020 Nair, Jolliffe, Lograsso and Bearden. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. Received: 04 April 2020; Accepted: 12 June 2020; Published: 25 June 2020. Author Contributions: AN and CB took the lead role in reviewing papers and drafting the manuscript. MJ and SL assisted in reviewing papers and preparing tables. All authors read and approved the final manuscript. All authors contributed to the article and approved the submitted version. This work was supported by the National Institute of Mental Health K99MH113820 (author AN). The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Funders:
Funding AgencyGrant Number
NIHK99MH113820
Subject Keywords:functional connectivity, default mode network, social cognition, autism spectrum disorder, early-onset psychosis
PubMed Central ID:PMC7330632
Record Number:CaltechAUTHORS:20200720-102909848
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20200720-102909848
Official Citation:Nair A, Jolliffe M, Lograsso YSS and Bearden CE (2020) A Review of Default Mode Network Connectivity and Its Association With Social Cognition in Adolescents With Autism Spectrum Disorder and Early-Onset Psychosis. Front. Psychiatry 11:614. doi: 10.3389/fpsyt.2020.00614
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:104445
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:20 Jul 2020 17:43
Last Modified:20 Jul 2020 17:43

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