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Anatomical analysis of an aye-aye brain (Daubentonia madagascariensis, primates: Prosimii) combining histology, structural magnetic resonance imaging, and diffusion-tensor imaging

Kaufman, Jason A. and Ahrens, Eric T. and Laidlaw, David H. and Zhang, Songbo and Allman, John M. (2005) Anatomical analysis of an aye-aye brain (Daubentonia madagascariensis, primates: Prosimii) combining histology, structural magnetic resonance imaging, and diffusion-tensor imaging. The Anatomical Record Part A: Discoveries in Molecular, Cellular, and Evolutionary Biology, 287A (1). pp. 1026-1037. ISSN 1552-4884. https://resolver.caltech.edu/CaltechAUTHORS:20200721-162844914

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Abstract

This report presents initial results of a multimodal analysis of tissue volume and microstructure in the brain of an aye‐aye (Daubentonia madagascariensis ). The left hemisphere of an aye‐aye brain was scanned using T2‐weighted structural magnetic resonance imaging (MRI) and diffusion‐tensor imaging (DTI) prior to histological processing and staining for Nissl substance and myelinated fibers. The objectives of the experiment were to estimate the volume of gross brain regions for comparison with published data on other prosimians and to validate DTI data on fiber anisotropy with histological measurements of fiber spread. Measurements of brain structure volumes in the specimen are consistent with those reported in the literature: the aye‐aye has a very large brain for its body size, a reduced volume of visual structures (V1 and LGN), and an increased volume of the olfactory lobe. This trade‐off between visual and olfactory reliance is likely a reflection of the nocturnal extractive foraging behavior practiced by Daubentonia . Additionally, frontal cortex volume is large in the aye‐aye, a feature that may also be related to its complex foraging behavior and sensorimotor demands. Analysis of DTI data in the anterior cingulum bundle demonstrates a strong correlation between fiber spread as measured from histological sections and fiber spread as measured from DTI. These results represent the first quantitative comparison of DTI data and fiber‐stained histology in the brain.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1002/ar.a.20264DOIArticle
Additional Information:© 2005 Wiley‐Liss, Inc. Issue Online: 25 October 2005. Version of Record online: 07 October 2005. Manuscript accepted: 17 August 2005. Manuscript received: 16 August 2005. The authors thank the Duke University Primate Center for providing the aye-aye brain and Virginie Goubert for expert assistance with histological preparation. Supported by the David and Lucile Packard Foundation (to J.M.A.), the Gordon and Betty Moore Foundation (to J.M.A.), the National Science Foundation (CCR-0086065 to D.H.L.), and the National Institutes of Health (RO1-EB003453, P41-EB001977, and P50-ES049617 to E.T.A.).
Funders:
Funding AgencyGrant Number
David and Lucile Packard FoundationUNSPECIFIED
Gordon and Betty Moore FoundationUNSPECIFIED
NSFCCR-0086065
NIHR01-EB003453
NIHP41-EB001977
NIHP50-ES049617
Subject Keywords:aye‐aye, Daubentonia, brain volume, histology, magnetic resonance imaging, diffusion‐tensor imaging
Issue or Number:1
Record Number:CaltechAUTHORS:20200721-162844914
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20200721-162844914
Official Citation:Kaufman, J.A., Ahrens, E.T., Laidlaw, D.H., Zhang, S. and Allman, J.M. (2005), Anatomical analysis of an aye‐aye brain (Daubentonia madagascariensis , primates: Prosimii) combining histology, structural magnetic resonance imaging, and diffusion‐tensor imaging. Anat. Rec., 287A: 1026-1037. doi:10.1002/ar.a.20264
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:104495
Collection:CaltechAUTHORS
Deposited By: Rebecca Minjarez
Deposited On:22 Jul 2020 16:45
Last Modified:22 Jul 2020 16:45

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