Mathias, Errol V. and Aponte, Julia and Kornfield, Julia A. and Ba, Yong (2010) Properties of small molecular drug loading and diffusion in a fluorinated PEG hydrogel studied by ¹H molecular diffusion NMR and ¹⁹F spin diffusion NMR. Colloid and Polymer Science, 288 (18). pp. 1655-1663. ISSN 0303-402X. https://resolver.caltech.edu/CaltechAUTHORS:20200728-174942361
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Abstract
R_f-PEG (fluoroalkyl double-ended poly(ethylene glycol)) hydrogel is potentially useful as a drug delivery depot due to its advanced properties of sol–gel two-phase coexistence and low surface erosion. In this study, ¹H molecular diffusion nuclear magnetic resonance (NMR) and ¹⁹F spin diffusion NMR were used to probe the drug loading and diffusion properties of the R_f-PEG hydrogel for small anticancer drugs, 5-fluorouracil (FU) and its hydrophobic analog, 1,3-dimethyl-5-fluorouracil (DMFU). It was found that FU has a larger apparent diffusion coefficient than that of DMFU, and the diffusion of the latter was more hindered. The result of ¹⁹F spin diffusion NMR for the corresponding freeze-dried samples indicates that a larger portion of DMFU resided in the R_f core/IPDU intermediate-layer region (where IPDU refers to isophorone diurethane, as a linker to interconnect the R_f group and the PEG chain) than that of FU while the opposite is true in the PEG–water phase. To understand the experimental data, a diffusion model was proposed to include: (1) hindered diffusion of the drug molecules in the R_f core/IPDU-intermediate-layer region; (2) relatively free diffusion of the drug molecules in the PEG-water phase (or region); and (3) diffusive exchange of the probe molecules between the above two regions. This study also shows that molecular diffusion NMR combined with spin diffusion NMR is useful in studying the drug loading and diffusion properties in hydrogels for the purpose of drug delivery applications.
Item Type: | Article | ||||||
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Additional Information: | © The Author(s) 2010. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited. Received: 8 June 2010; Revised: 19 September 2010; Accepted: 20 September 2010; Published online: 5 October 2010. This research was supported by the NSF Grant 0351848 and NSF Grant 0619147 for an NMR facility upgrade at CSULA. | ||||||
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Subject Keywords: | Fluoroalkyl double-ended poly(ethylene glycol), Hydrogel, 5-Fluorouracil, 1,3-Dimethyl-5-fluorouracil, Dug delivery, Molecular diffusion, Spin diffusion, NMR | ||||||
Issue or Number: | 18 | ||||||
Record Number: | CaltechAUTHORS:20200728-174942361 | ||||||
Persistent URL: | https://resolver.caltech.edu/CaltechAUTHORS:20200728-174942361 | ||||||
Official Citation: | Mathias, E.V., Aponte, J., Kornfield, J.A. et al. Properties of small molecular drug loading and diffusion in a fluorinated PEG hydrogel studied by 1H molecular diffusion NMR and 19F spin diffusion NMR. Colloid Polym Sci 288, 1655–1663 (2010). https://doi.org/10.1007/s00396-010-2304-9 | ||||||
Usage Policy: | No commercial reproduction, distribution, display or performance rights in this work are provided. | ||||||
ID Code: | 104627 | ||||||
Collection: | CaltechAUTHORS | ||||||
Deposited By: | Rebecca Minjarez | ||||||
Deposited On: | 10 Aug 2020 20:40 | ||||||
Last Modified: | 10 Aug 2020 20:40 |
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