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Rapid Detection Methods for Bacterial Pathogens in Ambient Waters at the Point of Sample Collection: A Brief Review

Li, Jing and Zhu, Yanzhe and Wu, Xunyi and Hoffmann, Michael R. (2020) Rapid Detection Methods for Bacterial Pathogens in Ambient Waters at the Point of Sample Collection: A Brief Review. Clinical Infectious Diseases, 71 (S2). S84-S90. ISSN 1058-4838. PMCID PMC7388722.

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The world is currently facing a serious health burden of waterborne diseases, including diarrhea, gastrointestinal diseases, and systemic illnesses. The control of these infectious diseases ultimately depends on the access to safe drinking water, properly managed sanitation, and hygiene practices. Therefore, ultrasensitive, rapid, and specific monitoring platforms for bacterial pathogens in ambient waters at the point of sample collection are urgently needed. We conducted a literature review on state-of-the-art research of rapid in-field aquatic bacteria detection methods, including cell-based methods, nucleic acid amplification detection methods, and biosensors. The detection performance, the advantages, and the disadvantages of the technologies are critically discussed. We envision that promising monitoring approaches should be automated, real-time, and target-multiplexed, thus allowing comprehensive evaluation of exposure risks attributable to waterborne pathogens and even emerging microbial contaminants such as antibiotic resistance genes, which leads to better protection of public health.

Item Type:Article
Related URLs:
URLURL TypeDescription CentralArticle
Zhu, Yanzhe0000-0002-2260-1830
Hoffmann, Michael R.0000-0001-6495-1946
Additional Information:© The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. Published: 09 July 2020; Corrected and typeset: 29 July 2020. This work was supported by the Bill & Melinda Gates Foundation (grant number OPP1111252 and OPP1192379). Supplement sponsorship: This supplement is funded with support from the Coalition against Typhoid Secretariat, housed at the Sabin Vaccine Institute in Washington, DC and made possible by a grant from the Bill & Melinda Gates Foundation. The authors: No reported conflicts of interest. All authors have submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest.
Funding AgencyGrant Number
Bill and Melinda Gates FoundationOPP1111252
Bill and Melinda Gates FoundationOPP1192379
Sabin Vaccine InstituteUNSPECIFIED
Subject Keywords:waterborne pathogens; exposure risk assessment; detection methods; rapidity; portability
Issue or Number:S2
PubMed Central ID:PMC7388722
Record Number:CaltechAUTHORS:20200729-144659561
Persistent URL:
Official Citation:Jing Li, Yanzhe Zhu, Xunyi Wu, Michael R Hoffmann, Rapid Detection Methods for Bacterial Pathogens in Ambient Waters at the Point of Sample Collection: A Brief Review, Clinical Infectious Diseases, Volume 71, Issue Supplement_2, 15 August 2020, Pages S84–S90,
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:104644
Deposited By: Tony Diaz
Deposited On:29 Jul 2020 21:57
Last Modified:10 Sep 2020 19:39

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