CaltechAUTHORS
  A Caltech Library Service

Global enhancement of cortical excitability following coactivation of large neuronal populations

Zhang, Deng and Yan, Xingjian and She, Liang and Wen, Yunqing and Poo, Mu-ming (2020) Global enhancement of cortical excitability following coactivation of large neuronal populations. Proceedings of the National Academy of Sciences of the United States of America, 117 (33). pp. 20254-20264. ISSN 0027-8424. https://resolver.caltech.edu/CaltechAUTHORS:20200803-144801580

[img]
Preview
PDF - Published Version
See Usage Policy.

4Mb
[img] PDF - Supplemental Material
See Usage Policy.

7Mb

Use this Persistent URL to link to this item: https://resolver.caltech.edu/CaltechAUTHORS:20200803-144801580

Abstract

Correlated activation of cortical neurons often occurs in the brain and repetitive correlated neuronal firing could cause long-term modifications of synaptic efficacy and intrinsic excitability. We found that repetitive optogenetic activation of neuronal populations in the mouse cortex caused enhancement of optogenetically evoked firing of local coactivated neurons as well as distant cortical neurons in both ipsilateral and contralateral hemispheres. This global enhancement of evoked responses required coactivation of a sufficiently large population of neurons either within one cortical area or distributed in several areas. Enhancement of neuronal firing was saturable after repeated episodes of coactivation, diminished by inhibition of N-methyl-D-aspartic acid receptors, and accompanied by elevated excitatory postsynaptic potentials, all consistent with activity-induced synaptic potentiation. Chemogenetic inhibition of neuronal activity of the thalamus decreased the enhancement effect, suggesting thalamic involvement. Thus, correlated excitation of large neuronal populations leads to global enhancement of neuronal excitability.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1073/pnas.1914869117DOIArticle
https://www.pnas.org/content/suppl/2020/07/31/1914869117.DCSupplementalPublisherSupporting Information
ORCID:
AuthorORCID
Zhang, Deng0000-0002-1523-9503
Yan, Xingjian0000-0002-6043-5837
Additional Information:© 2020 National Academy of Sciences. Contributed by Mu-ming Poo, July 3, 2020 (sent for review September 16, 2019; reviewed by Sydney S. Cash and Karunesh Ganguly). PNAS first published August 3, 2020. We thank Shengjin Xu, Qingfang Zhang, Chunfeng Shang, Haishan Yao, Wei Huang, Dechen Liu, Tianyi Wang, Wenhui Qiao, and Dinghong Zhang for technical advice and support. This work was supported by the Strategic Priority Research Program of the Chinese Academy of Sciences (Grant XDB32070100), Key Research Program of Frontier Sciences, Chinese Academy of Sciences (QYZDY-SSW-SMCO01), International Partnership Program of Chinese Academy of Sciences (153D31KYSB20170059), the Shanghai Key Basic Research Project (16JC1420201), Shanghai Municipal Science and Technology Major Project (2018SHZDZX05), and the Shanghai Key Basic Research Project (18JC1410100). Data Availability: All study data are included in the article and SI Appendix. D.Z. and X.Y. contributed equally to this work. Author contributions: D.Z., X.Y., and M.-m.P. designed research; D.Z. and X.Y. performed research; D.Z., X.Y., L.S., and Y.W. contributed new reagents/analytic tools; D.Z., X.Y., L.S., and Y.W. analyzed data; and D.Z., X.Y., and M.-m.P. wrote the paper. Reviewers: S.S.C., Massachusetts General Hospital; and K.G., University of California, San Francisco. The authors declare no competing interest. This article contains supporting information online at https://www.pnas.org/lookup/suppl/doi:10.1073/pnas.1914869117/-/DCSupplemental.
Funders:
Funding AgencyGrant Number
Chinese Academy of SciencesXDB32070100
Chinese Academy of SciencesQYZDY-SSW-SMCO01
Chinese Academy of Sciences153D31KYSB20170059
Shanghai Key Basic Research Project16JC1420201
Shanghai Municipal Science and Technology Major Project2018SHZDZX05
Shanghai Key Basic Research Project18JC1410100
Subject Keywords:activity-dependent plasticity; synaptic potentiation; global excitability; cortical wave; corticothalamocortical circuit
Issue or Number:33
Record Number:CaltechAUTHORS:20200803-144801580
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20200803-144801580
Official Citation:Global enhancement of cortical excitability following coactivation of large neuronal populations. Deng Zhang, Xingjian Yan, Liang She, Yunqing Wen, Mu-ming Poo. Proceedings of the National Academy of Sciences Aug 2020, 117 (33) 20254-20264; DOI: 10.1073/pnas.1914869117
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:104709
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:03 Aug 2020 21:59
Last Modified:19 Aug 2020 19:48

Repository Staff Only: item control page