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Polo-like kinases: a team that plays throughout mitosis

Glover, David M. and Hagan, Iain M. and Tavares, Álvaro A. M. (1998) Polo-like kinases: a team that plays throughout mitosis. Genes and Development, 12 (24). pp. 3777-3787. ISSN 0890-9369. doi:10.1101/gad.12.24.3777.

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When the first mutant allele of the Drosophila genepolo was first characterized over 10 years ago, attention focused on the defects that centrosome behavior exhibited at various stages of development (Sunkel and Glover 1988). The subsequent realization that the serine-threonine kinase it encodes is highly conserved from yeasts to humans has provoked a flurry of investigation into the function of the enzyme. A role for the polo-like kinases (plks) in regulating centrosome behavior has been borne out in several organisms, and the enzymes have attracted further attention recently with the realization that they regulate multiple stages of mitotic progression. In this article we review the current status of our understanding of the functions of plks from the time of commitment to M phase in the activation of Cdc25, through the activation of the anaphase promoting complex (APC), to the regulation of late mitotic events essential for cytokinesis. We discuss how to reconcile the sometimes apparently disparate observations made upon plk function in different organisms.

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Glover, David M.0000-0003-0956-0103
Additional Information:© 1998 by Cold Spring Harbor Laboratory Press. The Authors acknowledge that six months after the full-issue publication date, the Article will be distributed under a Creative Commons CC-BY-NC License (Attribution-NonCommercial 4.0 International License, The work in our laboratories is supported by the Cancer Research Campaign, Biotechnology and Biological Sciences Council Research, and the Training and Mobility of Researchers scheme of the European Union. We are grateful to several colleagues, particularly Carmo Avides, for their comments on the manuscript.
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Cancer Research CampaignUNSPECIFIED
Biotechnology and Biological Sciences Research Council (BBSRC)UNSPECIFIED
Marie Curie FellowshipUNSPECIFIED
Issue or Number:24
Record Number:CaltechAUTHORS:20200807-170353198
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Official Citation:Polo-like kinases: a team that plays throughout mitosis David M. Glover, Iain M. Hagan, and Álvaro A.M. Tavares Genes Dev. December 15, 1998 12: 3777-3787; doi:10.1101/gad.12.24.3777
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:104861
Deposited By: George Porter
Deposited On:20 Aug 2020 17:33
Last Modified:16 Nov 2021 18:37

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