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Editorial: Aurora Kinases: Classical Mitotic Roles, Non-Canonical Functions and Translational Views

Pérez de Castro, Ignacio and Carmena, Mar and Prigent, Claude and Glover, David M. (2017) Editorial: Aurora Kinases: Classical Mitotic Roles, Non-Canonical Functions and Translational Views. Frontiers in Oncology, 7 . Art. No. 48. ISSN 2234-943X. PMCID PMC5360697. doi:10.3389/fonc.2017.00048. https://resolver.caltech.edu/CaltechAUTHORS:20200807-170353624

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Abstract

Aurora kinases are key mitotic regulators that have also been associated with tumor development and progression. The interest on this highly conserved family of protein kinases has grown exponentially since they were discovered in the 1990s. Despite the steady increase in the number of laboratories involved and the consequent boost of the volume of research output during the last years, the study of Aurora kinases remains a very dynamic area in which new discoveries frequently keep coming to light. From a clinical perspective, the interest on Aurora kinase biology stems from their identification as targets for drug development; an increasing number of Aurora kinase inhibitors are being tested in preclinical projects and clinical trials. In this Frontiers Research Topic, we have aimed to not only review and revisit different aspects of the functions and regulation of Aurora kinases but also provide a forum for the publication of new developments in the field. We have been privileged to count on contributions from authors and reviewers that include some of the most experienced voices in our research area. In their introductory article to the Research Topic, two old-timers in the field, David Glover and Bill Earnshaw, have provided a historical perspective of Aurora Kinase research. By looking at the field’s origin using genetic screens in Drosophila and yeast and cell biological studies in vertebrates that led to the identification of Aurora kinases and their partner proteins, the authors give us a unique first witness account of the development of the field (Carmena et al.).


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.3389/fonc.2017.00048DOIArticle
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5360697/PubMed CentralArticle
ORCID:
AuthorORCID
Carmena, Mar0000-0002-2352-1066
Prigent, Claude0000-0001-8515-8699
Glover, David M.0000-0003-0956-0103
Additional Information:© 2017 Pérez de Castro, Carmena, Prigent and Glover. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. Received: 02 February 2017; Accepted: 08 March 2017; Published: 22 March 2017. Editorial on the Research Topic: Aurora Kinases: Classical Mitotic Roles, Non-Canonical Functions and Translational Views Work in our laboratories is supported by grants from Ministerio de Economía, Industría y Competitividad (SAF SAF2016-76929-R), Ligue Nationale Contre le Cancer (LNCC, équipe labelisée 2014-2016), and Wellcome Trust (073915, 077707, and 092076). Author Contributions: The authors are the editors of the Research Topic “Aurora kinases: classical mitotic roles, non-canonical functions, and translational views.” The four have equally contributed to this editorial. The authors declare that the work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Funders:
Funding AgencyGrant Number
Ministerio de Economía, Industría y Competitividad (MINECO)SAF2016-76929-R
Ligue Nationale Contre le CancerUNSPECIFIED
Wellcome Trust073915
Wellcome Trust077707
Wellcome Trust092076
Subject Keywords:aurora kinase, mitosis, antitumoral therapy, aurora inhibitors, non-canonical roles
PubMed Central ID:PMC5360697
DOI:10.3389/fonc.2017.00048
Record Number:CaltechAUTHORS:20200807-170353624
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20200807-170353624
Official Citation:Pérez de Castro I, Carmena M, Prigent C, Glover DM. Editorial: Aurora Kinases: Classical Mitotic Roles, Non-Canonical Functions and Translational Views. Front Oncol. 2017;7:48. Published 2017 Mar 22. doi:10.3389/fonc.2017.00048
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:104865
Collection:CaltechAUTHORS
Deposited By: George Porter
Deposited On:20 Aug 2020 16:49
Last Modified:16 Nov 2021 18:37

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